INT143993

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Prdx2, Atp13a4) cytosol (Prdx2) mitochondrion (Prdx2)
oxidoreductase activity (Prdx2) ATPase activity (Atp13a4) cellular_component (Atp13a4)
Anatomy Link Frequency
vesicles 1
Prdx2 (Rattus norvegicus)
Atp13a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 3 56.88 Quite High
Angina 1 37.56 Quite Low
Disease Link Frequency Relevance Heat
Stroke 1 39.68 Quite Low
Hyperlipidemia 1 39.24 Quite Low
Myocardial Infarction 1 38.60 Quite Low
Cv General 3 Under Development 1 37.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, TSA significantly inhibited P-gp-mediated transport of digoxin in P-gp-overexpressing membrane vesicles with an IC(50) of 2.6 microM, but stimulated vanadate-sensitive P-gp ATPase activity with estimated K(m) and V(max) values of 10.70 +/- 0.69 microM and 67.65 +/- 1.31 nmol/min/mg protein, respectively.
TSA Positive_regulation (stimulated) of P-gp ATPase in vesicles
1) Confidence 0.00 Published 2007 Journal Curr. Drug Metab. Section Abstract Doc Link 17504222 Disease Relevance 0 Pain Relevance 0.05

General Comments

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