INT143998

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 2.44
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
striatum 2
upper 2
neuronal 1
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 408 100.00 Very High Very High Very High
Enkephalin 27 98.76 Very High Very High Very High
depression 4 95.68 Very High Very High Very High
substance P 3 95.32 Very High Very High Very High
Dynorphin 3 94.72 High High
Action potential 30 89.96 High High
antagonist 2 85.32 High High
agonist 15 84.72 Quite High
Crohn's disease 4 84.12 Quite High
chemokine 14 71.24 Quite High
Disease Link Frequency Relevance Heat
Disease 110 99.00 Very High Very High Very High
Paratuberculosis 12 98.84 Very High Very High Very High
Depression 6 95.68 Very High Very High Very High
Sprains And Strains 28 91.52 High High
Hypertrophy 2 90.20 High High
Stress 11 71.56 Quite High
INFLAMMATION 53 66.36 Quite High
Syndrome 7 57.16 Quite High
Hypersensitivity 2 52.84 Quite High
Infection 9 52.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we were interested to investigate the variability of susceptibility to antimycobacterial compounds of the MAP isolates with respect to growth in agar medium and Congo red (a planar hydrophobic molecule that binds to lipids and lipoproteins, which are abundant in mycobacterial cell walls) staining properties.
red Binding (binds) of associated with paratuberculosis
1) Confidence 0.34 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1705807 Disease Relevance 1.38 Pain Relevance 0.22
However, the upper respiratory irritation and discomfort caused by inhaling aerosolized red tide toxins can be substantial.
red Binding (inhaling) of in upper
2) Confidence 0.21 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257562 Disease Relevance 0 Pain Relevance 0
However, the upper respiratory irritation and discomfort caused by inhaling aerosolized red tide toxins can be substantial.
red Binding (aerosolized) of in upper
3) Confidence 0.21 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257562 Disease Relevance 0 Pain Relevance 0
These results demonstrate that Ik-1 and Ik-2 proteins through their DNA binding act as positive regulators of ENK gene expression in the developing striatum and participate in regulating enkephalinergic differentiation.
Ik Binding (binding) of in striatum associated with enkephalin
4) Confidence 0.14 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.66
These results demonstrate that Ik-1 and Ik-2 proteins through their DNA binding act as positive regulators of ENK gene expression in the developing striatum and participate in regulating enkephalinergic differentiation.
Ik Binding (binding) of in striatum associated with enkephalin
5) Confidence 0.14 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.66
Blocking the DNA binding of Ik proteins in differentiating embryonic striatal neuronal cultures resulted in decreased ENK expression and mutant animals lacking the DNA-binding domain of Ik had a deficit in the number of ENK but not in dynorphin or substance P mRNA+ cells.
Ik Binding (binding) of in neuronal associated with dynorphin, enkephalin and substance p
6) Confidence 0.11 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17504264 Disease Relevance 0 Pain Relevance 0.69
Due to the synergistic action of IK,CCh and ICa, it is impossible to provide exact quantitative estimates on the relative importance of IK,CCh and ICa in the negative inotropic effect of CCh, even though IK,CCh seems to be more important.
IK Binding (seems) of
7) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.10 Pain Relevance 0.22
Surprisingly, despite evidence of unregulated activation, Rab7 disease mutants have normal subcellular localization and associate normally with LAMP2 (Fig. 5B) and LysoTracker Red (data not shown).
Red Binding (associate) of associated with disease
8) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.51 Pain Relevance 0
Cytokine receptors are composed of subunits that form higher order complexes following cytokine binding.
cytokine Binding (binding) of associated with cytokine
9) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.39 Pain Relevance 0.59
For example, crystallographic analysis of the shared use of receptors by IL4 and IL13 demonstrates that differences in the structural dynamics of receptor-cytokine engagement can specify unique signaling outcomes even when an identical receptor heterodimer in a defined cell and context is engaged (LaPorte et al., 2008).
cytokine Binding (engagement) of associated with cytokine
10) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.06 Pain Relevance 0.38
A single PCR primer that binds to each IS element, and primers specific to a region ~500-bp upstream of each of the 20 IS1111 elements were designed.
IS element Binding (binds) of
11) Confidence 0.01 Published 2007 Journal BMC Microbiol Section Abstract Doc Link PMC2104537 Disease Relevance 0 Pain Relevance 0
This estrogenic binding affinity of phenol red is close to that of 17?
phenol red Binding (affinity) of
12) Confidence 0.01 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1131924 Disease Relevance 0 Pain Relevance 0

General Comments

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