INT144

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Context Info
Confidence 0.64
First Reported 1977
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.77
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
smooth muscles 1
band 1
nucleus 1
neural 1
H1 (Mus musculus)
Pain Link Frequency Relevance Heat
Antihistamine 9 100.00 Very High Very High Very High
Morphine 16 99.90 Very High Very High Very High
Central nervous system 2 99.76 Very High Very High Very High
Antinociceptive 4 99.50 Very High Very High Very High
antagonist 26 98.96 Very High Very High Very High
Perioperative pain 1 98.08 Very High Very High Very High
Analgesic 4 96.88 Very High Very High Very High
anesthesia 3 96.00 Very High Very High Very High
antinociception 3 91.68 High High
noradrenaline 1 87.44 High High
Disease Link Frequency Relevance Heat
Anaphylaxis 5 99.54 Very High Very High Very High
Targeted Disruption 6 99.40 Very High Very High Very High
Vomiting 60 98.48 Very High Very High Very High
Post Operative Pain 1 98.08 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.00 Very High Very High Very High
Shock 3 97.04 Very High Very High Very High
Respiratory Sounds 1 91.44 High High
Birth Weight 3 88.20 High High
Congenital Anomalies 2 87.52 High High
Sleep Disorders 2 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data thus suggest that histamine excites nucleus basalis cholinergic neurons by a concomitant activation of H1 and H2 receptors.
Positive_regulation (activation) of H1 in nucleus
1) Confidence 0.64 Published 1995 Journal Neuroscience Section Abstract Doc Link 8552244 Disease Relevance 0 Pain Relevance 0.31
The contribution of H1- and H2-receptors to the effect of morphine on maximal electroconvulsive shock in mice was investigated in the present experiments.
Spec (investigated) Positive_regulation (contribution) of H1 associated with shock and morphine
2) Confidence 0.46 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8835636 Disease Relevance 0.25 Pain Relevance 0.73
The pathophysiologic effects of histamine in anaphylaxis have been shown to be mediated through H1 and H2 receptors, individually and in combination.
Positive_regulation (mediated) of H1 associated with anaphylaxis
3) Confidence 0.42 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1977785 Disease Relevance 0.56 Pain Relevance 0.13
Stimulation of H1 or H2-receptor produces excitatory or inhibitory effects, respectively, on the smooth muscles and on the adrenergic nerves.
Positive_regulation (Stimulation) of H1 in smooth muscles
4) Confidence 0.41 Published 1983 Journal Pflugers Arch. Section Abstract Doc Link 6647000 Disease Relevance 0 Pain Relevance 0.16
Thus, neural effects are mediated by the occupation of H1 receptors (presumably on the submucosal neurons), whereas the non-neural (direct) effects result from the occupation of either H1 or H2 receptors.
Positive_regulation (occupation) of H1 in neural
5) Confidence 0.38 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965764 Disease Relevance 0 Pain Relevance 0.55
It is concluded that a) central hemodynamic responses do not seem to be mediated through specific H1 and H2 receptors; b) histamine-induced pulmonary vasoconstriction can be reversed by pentobarbital anesthesia, and c) the absence of circulatory response to intrapulmonary histamine administration suggests that whatever receptors that may exist in the pulmonary vascular bed are not necessary for the central hemodynamic effects.
Positive_regulation (mediated) of H1 associated with anesthesia and increased venous pressure under development
6) Confidence 0.35 Published 1977 Journal Am. J. Physiol. Section Abstract Doc Link 13663 Disease Relevance 0.34 Pain Relevance 0.18
We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice.
Positive_regulation (enhanced) of H1 associated with targeted disruption, antinociceptive and morphine
7) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16806305 Disease Relevance 0.53 Pain Relevance 0.86
30 °C, the conformation of the receptor is considerably more evolved toward an active state conformation than in the Meta I state of E181Q stabilized at a similar temperature, as evident from the conformational changes in the H1/H2/H7 microdomain and the amide I marker band analysis.
Positive_regulation (changes) of H1 in band
8) Confidence 0.10 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
1 comparable to that in Meta II, indicating a full rearrangement of the involved H1/H2/H7 network to an active state conformation in this Meta II precursor state at ? 
Positive_regulation (rearrangement) of H1
9) Confidence 0.10 Published 2008 Journal J Mol Biol Section Body Doc Link PMC2726285 Disease Relevance 0 Pain Relevance 0
Clinical evaluation of H1-receptor and H2-receptor antagonists for acute postoperative pain.
Positive_regulation (evaluation) of H1 associated with antagonist and perioperative pain
10) Confidence 0.09 Published 1993 Journal J Clin Pharmacol Section Title Doc Link 8227466 Disease Relevance 0.24 Pain Relevance 0.98
Other H1-blocker antihistamines such as dimenhydrinate (Gravol®) and diphenhydramine (Benadryl®), have been used for NVP treatment without safety concerns.
Positive_regulation (used) of H1 associated with antihistamine
11) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990891 Disease Relevance 0.85 Pain Relevance 0.24

General Comments

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