INT144010

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.40
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb6) response to stress (Hspb6) cytoplasm (Hspb6)
Anatomy Link Frequency
myometrium 3
muscle 2
longitudinal muscle 1
Hspb6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 9 97.32 Very High Very High Very High
Glutamate 144 92.08 High High
Morphine 1 31.32 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 18 100.00 Very High Very High Very High
Dysmenorrhea 9 97.32 Very High Very High Very High
Death 68 92.84 High High
Ganglion Cysts 3 87.92 High High
Parkinson's Disease 1 87.52 High High
Apoptosis 68 78.64 Quite High
Osteoporosis 1 40.72 Quite Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heat shock protein 20 (HSP20) is known to be present at high levels in smooth muscle and implicated in muscle relaxation, but HSP20 expression in the myometrium is completely undetermined.
Gene_expression (expression) of HSP20 in muscle associated with shock
1) Confidence 0.78 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.27 Pain Relevance 0.09
Expression of small heat shock-related protein 20 (HSP20) in rat myometrium is markedly decreased during late pregnancy and labour.
Gene_expression (Expression) of HSP20 in myometrium associated with shock
2) Confidence 0.78 Published 2007 Journal Reproduction Section Title Doc Link 17504924 Disease Relevance 0.29 Pain Relevance 0.10
Since HSP20 has been implicated in smooth muscle relaxation, we hypothesized that HSP20 would be highly expressed in the rat myometrium during early and mid-pregnancy when the myometrium is relatively quiescent.
Gene_expression (expressed) of HSP20 in myometrium
3) Confidence 0.78 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.25 Pain Relevance 0.09
Heat shock protein 20 (HSP20) is known to be present at high levels in smooth muscle and implicated in muscle relaxation, but HSP20 expression in the myometrium is completely undetermined.
Gene_expression (expression) of HSP20 in muscle associated with shock
4) Confidence 0.78 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.27 Pain Relevance 0.10
The observed patterns of HSP20 expression are consistent with a potential role for HSP20 in facilitating myometrium quiescence during early and mid-pregnancy.
Gene_expression (expression) of HSP20 in myometrium
5) Confidence 0.78 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.07 Pain Relevance 0
Our results demonstrate that HSP20 mRNA and protein are highly expressed during early and mid-pregnancy and then the expression markedly decreases during late pregnancy and labour.
Gene_expression (expressed) of HSP20 mRNA
6) Confidence 0.78 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.07 Pain Relevance 0
Immunoblot analysis showed that detection of HSP20 was significantly decreased at d23 compared with d12 and d15 (P < 0.05).
Gene_expression (detection) of HSP20
7) Confidence 0.68 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.21 Pain Relevance 0.07
Northern blot analysis particularly demonstrated that HSP20 mRNA detection was significantly decreased from day (d) 22 of pregnancy to 1-day post-partum (PP) compared with d6 (P < 0.05).
Gene_expression (detection) of HSP20 mRNA
8) Confidence 0.68 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.24 Pain Relevance 0.08
In addition, HSP20 was detectable near cell membranes at much higher levels in the longitudinal muscle layer of progesterone-treated pregnant rats (delayed labour) at all gestational time points examined, compared with controls.
Gene_expression (detectable) of HSP20 in longitudinal muscle
9) Confidence 0.60 Published 2007 Journal Reproduction Section Abstract Doc Link 17504924 Disease Relevance 0.19 Pain Relevance 0.05
Although we were unable to directly detect by Western blot analysis, the active caspase-3 fragments p20 and p11, the presence of active caspase-3 was confirmed as discussed above.
Neg (unable) Gene_expression (detect) of p20
10) Confidence 0.20 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.45 Pain Relevance 0.08
We next focused on the general pattern of CD81, EBP50 and Sap97, at two time points, P2 (Figure 6) and P20 (Figure 5).
Gene_expression (pattern) of P20
11) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.09 Pain Relevance 0

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