INT144020

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 24.80
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
hepatocyte 1
lungs 1
mesenchymal cells 1
pulmonary artery 1
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 4 97.96 Very High Very High Very High
Central nervous system 13 97.08 Very High Very High Very High
fibrosis 206 93.52 High High
cytokine 116 93.00 High High
Serotonin 4 88.28 High High
chemokine 39 82.80 Quite High
Inflammation 173 82.08 Quite High
cINOD 14 81.68 Quite High
Inflammatory response 16 73.84 Quite High
metalloproteinase 59 72.92 Quite High
Disease Link Frequency Relevance Heat
Glioma 56 99.96 Very High Very High Very High
Cancer 1774 99.84 Very High Very High Very High
Genetic Translocation 1 99.44 Very High Very High Very High
Chronic Myelomonocytic Leukemia 15 99.26 Very High Very High Very High
Targeted Disruption 35 98.40 Very High Very High Very High
Hypertension 18 97.96 Very High Very High Very High
Fibrosis 174 96.52 Very High Very High Very High
Gastrointestinal Stromal Tumor 107 96.40 Very High Very High Very High
Experimental Melanoma 63 95.84 Very High Very High Very High
Desmoid Disease 33 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of PDGFRbeta may occur through oxidation of a catalytic cysteine of tyrosine phosphatase. 5-HT-activated PDGFRbeta phosphorylation is blocked by the antioxidant N-acetyl-L-cysteine and the NADPH oxidase inhibitor, DPI.
Positive_regulation (Activation) of PDGFRbeta
1) Confidence 0.69 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.23 Pain Relevance 0.13
Inhibition of PDGFR kinase with imatinib or AG1296 blocks 5-HT-stimulated PDGFRbeta phosphorylation. 5-HTT inhibitors and the Na+/K+-ATPase inhibitor ouabain, but not 5-HT2 and 5-HT1B/1D receptor inhibitors, block PDGFRbeta activation by 5-HT.
Positive_regulation (activation) of PDGFRbeta
2) Confidence 0.50 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.25 Pain Relevance 0.13
In summary, these results demonstrate that 5-HT transactivates PDGFRbeta in PASMCs leading to SMC proliferation and migration, and may be an important signaling pathway in the production of PH in vivo.
Positive_regulation (transactivates) of PDGFRbeta associated with hypertension
3) Confidence 0.50 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.27 Pain Relevance 0.08
Third, genotypic expression of B2A1 cells as seen with RT-PCR analysis demonstrates mRNA for nestin, Notch1, and PDGFR-?
Positive_regulation (demonstrates) of PDGFR
4) Confidence 0.49 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.17 Pain Relevance 0.09
In agreement with this, we found that tumors grew faster in mice with activated PDGFR-?
Positive_regulation (activated) of PDGFR associated with cancer
5) Confidence 0.47 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.05 Pain Relevance 0
We have recently generated a mouse model carrying a mutation in the corresponding amino acid residue in the activation loop of the murine PDGFR-?
Positive_regulation (activation) of PDGFR
6) Confidence 0.47 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.57 Pain Relevance 0
We have recently generated a mouse model carrying an activated PDGFR-?
Positive_regulation (activated) of PDGFR
7) Confidence 0.47 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 1.10 Pain Relevance 0
Recently, increased PDGFR-?
Positive_regulation (increased) of PDGFR
8) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.97 Pain Relevance 0
Our findings suggest that the activated PDGFR-?
Positive_regulation (activated) of PDGFR
9) Confidence 0.43 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.96 Pain Relevance 0
Recently, PDGF receptor signaling was shown to be perturbed by mutations within the activation loop of PDGFR-?
Positive_regulation (activation) of PDGFR
10) Confidence 0.41 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.72 Pain Relevance 0.03
Activated PDGFR-?
Positive_regulation (Activated) of PDGFR
11) Confidence 0.41 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.20 Pain Relevance 0
This implies that a more active stromal compartment probably drives the improved vascularization during tumor establishment in mice carrying an activated PDGFR-?.
Positive_regulation (activated) of PDGFR associated with cancer
12) Confidence 0.41 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.00 Pain Relevance 0
We present evidence for the first time that 5-HT transactivates PDGFRbeta through the 5-HTT in pulmonary artery (PA) SMCs.
Positive_regulation (transactivates) of PDGFRbeta in pulmonary artery
13) Confidence 0.40 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.29 Pain Relevance 0.11
This allowed us to investigate, in an orthotopic tumor model, the role of increased stromal PDGFR-?
Positive_regulation (increased) of PDGFR associated with cancer
14) Confidence 0.38 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 1.20 Pain Relevance 0
Using in situ hybridization and immunohistochemistry techniques, Hermanson et al demonstrated the presence of autocrine and paracrine loops in gliomas, activating the PDGFR-?
Positive_regulation (activating) of PDGFR associated with glioma
15) Confidence 0.34 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.02 Pain Relevance 0
The activation of PDGFR-?
Positive_regulation (activation) of PDGFR
16) Confidence 0.34 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.08 Pain Relevance 0.03
The function of BCR-ABL has allowed the design and development of imatinib, a small-molecule kinase inhibitor that targets PDGFR, c-Kit, and ABL kinases (Deininger et al 2005).
Positive_regulation (targets) of PDGFR
17) Confidence 0.33 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 1.11 Pain Relevance 0.05
A subset of patients with monocytosis, whom clinically appear to have a CMML like MPD have an imatinib sensitive rearrangement of PDGFRB arising from chromosomal translocations involving 5q33; such as t(5; 12)(q33; p13) or t(5; 7)(q33; q11.2)(Ross et al 1998).
Positive_regulation (rearrangement) of PDGFRB associated with chronic myelomonocytic leukemia and genetic translocation
18) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721304 Disease Relevance 1.72 Pain Relevance 0
On the one hand, treatment with imatinib/gleevec disrupted an autocrine PDGF/PDGFR loop by specifically inhibiting phosphorylation of PDGFR and thus exerted a synergistic antitumoral effect with ionising radiation as radiosensitizer [54].
Positive_regulation (autocrine) of PDGFR
19) Confidence 0.24 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.15 Pain Relevance 0.10
The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.
Positive_regulation (activation) of PDGFR in lungs
20) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.94 Pain Relevance 0.28

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