INT144021

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.53
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
vasculature 1
Atlas 1
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 2 98.12 Very High Very High Very High
Serotonin 1 74.96 Quite High
fibrosis 18 74.76 Quite High
metalloproteinase 28 72.00 Quite High
Kinase C 2 71.84 Quite High
Potency 9 44.92 Quite Low
Antiemetics 1 37.68 Quite Low
adenocard 2 37.48 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cell Carcinoma 100 99.84 Very High Very High Very High
Malignant Neoplastic Disease 25 98.22 Very High Very High Very High
Pressure And Volume Under Development 30 96.64 Very High Very High Very High
Lung Cancer 138 93.56 High High
Experimental Melanoma 7 93.48 High High
Targeted Disruption 4 92.96 High High
Solid Tumor 11 92.80 High High
Death 4 88.32 High High
Syndrome 4 87.76 High High
Genetic Translocation 2 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, 5-HTT binds the PDGFRbeta upon 5-HT stimulation and the 5-HTT inhibitor fluoxetine blocks both the binding and PDGDRbeta activation.
PDGFRbeta Binding (binds) of associated with fluoxetine
1) Confidence 0.37 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.25 Pain Relevance 0.14
are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-?
PDGFR Binding (endothelial cells) of in vasculature
2) Confidence 0.30 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.63 Pain Relevance 0
The receptor TKs c-KIT, murine PDGFR-?
PDGFR Binding (receptor) of
3) Confidence 0.20 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.18 Pain Relevance 0
A second mechanism of TK dysfunction in malignant cells is via the overexpression of a TK or its ligand; eg, the overexpression of VEGFR, PDGFR, or EGFR or their ligands in RCC (Gomella et al 1989; Mydlo et al 1989; Atlas et al 1992; Uhlman et al 1995; Iliopoulos et al 1996; Ramp et al 2000; Gunningham et al 2001; Na et al 2003; Sulzbacher et al 2003, Yildiz et al 2004; Minardi et al 2005; Xu et al 2005).
PDGFR Binding (ligands) of in Atlas associated with malignant neoplastic disease and renal cell carcinoma
4) Confidence 0.20 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.67 Pain Relevance 0.04
PDGF exerts its biological activity by binding to structurally similar PDGF receptors (PDGFR-?
PDGFR Binding (binding) of
5) Confidence 0.17 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.38 Pain Relevance 0.04
Although nilotinib and imatinib exhibit great selectivity for Bcr-Abl, Kit and Pdgf-R, these agents bind these kinases with different affinities.
Pdgf-R Binding (bind) of
6) Confidence 0.12 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761189 Disease Relevance 0.14 Pain Relevance 0
Mice with homozygous deletions of PDGF-B or PDGFR-?
PDGFR Binding (Mice) of
7) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 2.21 Pain Relevance 0
This functional PDGF-B-like protein form homodimers and, by an autocrine and paracrine loops, promote ligand driving proliferation through the two receptors PDGFR?
PDGFR Binding (receptors) of
8) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.38 Pain Relevance 0
A similar autocrine loop may exist for PDGF and its receptor PDGFR (Ascoli, 1995; Langerak, 1996; Klominek, 1998a).
PDGFR Binding (receptor) of
9) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.69 Pain Relevance 0.07

General Comments

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