INT144023

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 1 92.72 High High
Serotonin 1 77.00 Quite High
antagonist 2 46.64 Quite Low
cytokine 9 34.84 Quite Low
fibrosis 17 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastrointestinal Stromal Tumor 2 94.96 High High
Hypertension 4 86.68 High High
Cancer 42 82.92 Quite High
Desmoid Disease 4 79.56 Quite High
Recurrence 1 69.84 Quite High
Anaplastic Astrocytoma 2 59.68 Quite High
Malignant Neoplastic Disease 2 59.16 Quite High
Meningioma 1 48.16 Quite Low
Leukemia 1 46.32 Quite Low
Neuroblastoma 1 38.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of PDGFR kinase with imatinib or AG1296 blocks 5-HT-stimulated PDGFRbeta phosphorylation. 5-HTT inhibitors and the Na+/K+-ATPase inhibitor ouabain, but not 5-HT2 and 5-HT1B/1D receptor inhibitors, block PDGFRbeta activation by 5-HT.
Negative_regulation (block) of Positive_regulation (activation) of PDGFRbeta
1) Confidence 0.42 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.25 Pain Relevance 0.13
Approximately 35% of GISTs lacking KIT mutations have intragenic activation mutations in PDGFR-?
Negative_regulation (lacking) of Positive_regulation (activation) of PDGFR
2) Confidence 0.18 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.17 Pain Relevance 0

General Comments

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