INT144024

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.48
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Anatomy Link Frequency
smooth muscle cells 2
lungs 2
Pdgfrb (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 1 93.32 High High
fibrosis 34 90.00 High High
Inflammatory response 2 80.80 Quite High
Inflammation 12 74.40 Quite High
Serotonin 1 65.24 Quite High
tolerance 2 57.12 Quite High
cytokine 20 44.20 Quite Low
cINOD 2 24.72 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 143 97.76 Very High Very High Very High
Glioma 18 95.28 Very High Very High Very High
Apoptosis 4 95.28 Very High Very High Very High
Fibrosis 38 94.16 High High
Pulmonary Fibrosis 16 90.80 High High
Hypoxia 7 87.12 High High
Small Cell Lung Cancer 2 83.68 Quite High
Gastrointestinal Stromal Tumor 12 83.52 Quite High
INFLAMMATION 16 80.80 Quite High
Melanoma 3 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of PDGFRbeta may occur through oxidation of a catalytic cysteine of tyrosine phosphatase. 5-HT-activated PDGFRbeta phosphorylation is blocked by the antioxidant N-acetyl-L-cysteine and the NADPH oxidase inhibitor, DPI.
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of PDGFRbeta
1) Confidence 0.42 Published 2007 Journal FASEB J. Section Abstract Doc Link 17504974 Disease Relevance 0.22 Pain Relevance 0.13
In addition, both imatinib and nilotinib inhibited the phosphorylation of PDGFR-alpha tyrosine kinase with equivalent efficacy (Verstovsek et al 2006b).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of PDGFR-alpha tyrosine kinase
2) Confidence 0.38 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.16 Pain Relevance 0
Sorafenib also inhibited PDGFR autophosphorylation in primary human aortic smooth muscle cells (HAoSMCs); Flt-3 was also sensitive to inhibition of receptor phosphorylation by sorafenib in cell-based assays.
Negative_regulation (inhibited) of Phosphorylation (autophosphorylation) of PDGFR in smooth muscle cells
3) Confidence 0.32 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.70 Pain Relevance 0
The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of PDGFR in lungs
4) Confidence 0.28 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.01 Pain Relevance 0.29
On the one hand, treatment with imatinib/gleevec disrupted an autocrine PDGF/PDGFR loop by specifically inhibiting phosphorylation of PDGFR and thus exerted a synergistic antitumoral effect with ionising radiation as radiosensitizer [54].
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of PDGFR
5) Confidence 0.28 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.16 Pain Relevance 0.10
In a seminal paper phosphorylation level of PDGFR?
Negative_regulation (level) of Phosphorylation (phosphorylation) of PDGFR
6) Confidence 0.06 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.24 Pain Relevance 0

General Comments

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