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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3, CCND1) cytoplasm (STAT3, CCND1) cytosol (STAT3, CCND1)
nucleus (STAT3, CCND1) intracellular (CCND1) enzyme binding (CCND1)
STAT3 (Homo sapiens)
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 3 50.00 Quite Low
antagonist 5 44.16 Quite Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
Inflammation 26 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 1 95.72 Very High Very High Very High
Apoptosis 151 94.32 High High
Fever 41 90.60 High High
Lung Cancer 7 87.72 High High
Cancer 126 86.84 High High
Multiple Myeloma 1 62.52 Quite High
Death 27 50.00 Quite Low
Colon Cancer 23 36.72 Quite Low
Adenocarcinoma 5 23.04 Low Low
Familial Adenomatous Polyposis 4 7.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.
STAT3 Regulation (regulated) of cyclin D1
1) Confidence 0.09 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.06 Pain Relevance 0
This study has demonstrated that the activation of Src leads to an activating phosphorylation of STAT3, a transcription factor known to regulate cyclin D1 transcription, an important positive regulator of cell proliferation.
STAT3 Regulation (regulate) of cyclin D1
2) Confidence 0.07 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.99 Pain Relevance 0

General Comments

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