INT144032

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (STAT3, BCL2) cytosol (STAT3, BCL2) nucleus (STAT3, BCL2)
transcription factor binding (STAT3, BCL2) nucleoplasm (STAT3) mitochondrion (BCL2)
STAT3 (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 43 50.00 Quite Low
qutenza 3 50.00 Quite Low
Inflammation 24 49.92 Quite Low
ischemia 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 27 100.00 Very High Very High Very High
Multiple Myeloma 54 92.08 High High
Hematologic Neoplasms 39 88.16 High High
Cancer 147 83.20 Quite High
Wound Healing 2 68.60 Quite High
Breast Cancer 6 57.28 Quite High
Metastasis 14 55.00 Quite High
Disease 13 54.08 Quite High
INFLAMMATION 27 49.92 Quite Low
Epstein-barr Virus 1 26.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.
STAT3 Regulation (regulated) of Bcl-2
1) Confidence 0.07 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.06 Pain Relevance 0
Stat3 regulates transactivation of several anti-apoptotic genes such as survivin, Bcl-2, and Mcl-1.
Stat3 Regulation (regulates) of Bcl-2 associated with apoptosis
2) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.80 Pain Relevance 0

General Comments

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