INT144035

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.58
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) aging (IL6) DNA binding (STAT3)
cytoplasm (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3)
IL6 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 3 99.48 Very High Very High Very High
Inflammatory response 2 92.56 High High
cytokine 64 90.72 High High
agonist 44 74.40 Quite High
Inflammation 45 50.00 Quite Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 17 97.52 Very High Very High Very High
Cancer 278 97.36 Very High Very High Very High
Hypoxia 5 93.40 High High
INFLAMMATION 54 92.56 High High
Acute-phase Reaction 1 89.68 High High
Colon Cancer 48 85.56 High High
Lung Cancer 16 78.40 Quite High
Apoptosis 99 73.04 Quite High
Leukemia 17 52.00 Quite High
Hematologic Neoplasms 39 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In carcinoma cell lines, the major trends included a strong STAT3 activation by LIF (ADLC, H125), an increased (ADLC, H23) or decreased STAT3 activation by IL-6 (H125, H324), a decreased ERK activation by EGF (H522), and a treatment-independent, constitutive activation of the ERK pathway (H23).
IL-6 Positive_regulation (activation) of STAT3 associated with carcinoma
1) Confidence 0.31 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.27 Pain Relevance 0.17
, and activation of STAT3 by IL-6 [4], [40].
IL-6 Positive_regulation (activation) of STAT3
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.43 Pain Relevance 0.05
Activation of the Jak/Stat3 pathway by IL-6 through its high affinity receptor, IL-6R?
IL-6 Positive_regulation (Activation) of Stat3
3) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.89 Pain Relevance 0.05
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
interleukin-6-inducible Positive_regulation (inducible) of STAT3 associated with qutenza
4) Confidence 0.01 Published 2007 Journal Clin. Cancer Res. Section Title Doc Link 17505005 Disease Relevance 0 Pain Relevance 0.30

General Comments

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