INT144038

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
Anatomy Link Frequency
SH2 1
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 3 91.28 High High
depression 1 56.80 Quite High
Arthritis 10 53.88 Quite High
Nicotine 1 53.76 Quite High
Inflammation 56 50.00 Quite Low
withdrawal 2 41.08 Quite Low
Inflammatory response 8 13.60 Low Low
Inflammatory mediators 2 8.56 Low Low
cytokine 35 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 27 99.76 Very High Very High Very High
Multiple Myeloma 9 95.52 Very High Very High Very High
Apoptosis 29 92.28 High High
Muscle Wasting Disease 1 65.04 Quite High
Dementia 8 62.68 Quite High
Appetite Loss 2 62.48 Quite High
Disease 27 62.36 Quite High
Depression 1 56.80 Quite High
Stress 4 56.24 Quite High
Osteomyelitis 1 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Trenerry et al. (2007), reported similar findings indicating that SOCS3 mRNA expression peaked 2 h after intense resistance exercise, coinciding with the peak in c-myc mRNA and p-STAT3 protein, after which p-STAT3 signaling was no longer evident.
Transcription (expression) of STAT3
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.13 Pain Relevance 0
Because the transcription factor signal transducer and activator of transcription 3 (STAT3) has been closely linked with tumorigenesis, we investigated the effect of this vanilloid on the STAT3 pathway in human multiple myeloma cells.
Transcription (transcription) of STAT3 associated with multiple myeloma
2) Confidence 0.50 Published 2007 Journal Clin. Cancer Res. Section Abstract Doc Link 17505005 Disease Relevance 0.10 Pain Relevance 0.17
The important participants in the Interleukin-6 signaling pathway include the Janus kinases (JAKs) Jak1, Jak2 and Tyk2, the signal transducers and activators of transcription STAT1 and STAT3, the tyrosine phosphatase SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase] and transcription factor NF-?
Transcription (transcription) of STAT3 in SH2
3) Confidence 0.28 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.34 Pain Relevance 0.06
Amongst the non-histone acetylation targets that via HDACi induced acetylation could potentially impart anti-cancer effect are transcription factors (p53, c-Myc, Smad7, BCL6, GATA, STAT3, NF-?
Transcription (transcription) of STAT3 associated with cancer
4) Confidence 0.07 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.43 Pain Relevance 0.03

General Comments

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