INT144039

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) DNA binding (STAT3) cytoplasm (STAT3)
signal transducer activity (STAT3) cell proliferation (STAT3) cytosol (STAT3)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 91.88 High High
Inflammation 24 54.32 Quite High
agonist 43 50.00 Quite Low
qutenza 3 50.00 Quite Low
ischemia 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 147 98.04 Very High Very High Very High
Acute-phase Reaction 1 93.28 High High
INFLAMMATION 27 91.52 High High
Hypoxia 5 79.00 Quite High
Multiple Myeloma 54 69.16 Quite High
Hematologic Neoplasms 39 50.00 Quite Low
Malignant Neoplastic Disease 11 47.92 Quite Low
Apoptosis 27 45.84 Quite Low
Precancerous Conditions 1 18.32 Low Low
Metastasis 14 8.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pervanadate reversed the capsaicin-induced down-regulation of STAT3, suggesting the involvement of a protein tyrosine phosphatase.
Negative_regulation (reversed) of Negative_regulation (regulation) of STAT3
1) Confidence 0.55 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17505005 Disease Relevance 0.07 Pain Relevance 0
Inhibition of Stat3 activation blocks HIF-1 and VEGF expression in vitro and inhibits tumor growth and angiogenesis in vivo [151].
Negative_regulation (Inhibition) of Negative_regulation (blocks) of Stat3 associated with cancer
2) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.78 Pain Relevance 0.07

General Comments

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