INT14404

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.15
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINF2) extracellular region (SERPINF2)
Anatomy Link Frequency
plasma 2
platelet 2
SERPINF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 10 100.00 Very High Very High Very High
cva 2 95.16 Very High Very High Very High
Analgesic 1 91.72 High High
Pain 4 90.76 High High
Angina 2 80.60 Quite High
abdominal pain 2 68.88 Quite High
Restless leg syndrome 1 67.68 Quite High
Inflammatory response 4 49.64 Quite Low
anesthesia 4 25.00 Low Low
long-term potentiation 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 43 99.98 Very High Very High Very High
Anaemia 1 99.06 Very High Very High Very High
Diarrhoea 41 98.72 Very High Very High Very High
Adhesions 6 97.92 Very High Very High Very High
Renal Failure 1 96.52 Very High Very High Very High
Hemorrhage 4 95.44 Very High Very High Very High
Cv General 3 Under Development 3 95.16 Very High Very High Very High
Hepatotoxicity 1 94.88 High High
Wound Healing 1 94.40 High High
Mixed Connective Tissue Disorder 1 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, alpha 2-antiplasmin was depleted.
Negative_regulation (depleted) of alpha 2-antiplasmin
1) Confidence 0.47 Published 1985 Journal Klin. Wochenschr. Section Abstract Doc Link 4046499 Disease Relevance 0.66 Pain Relevance 0.32
Passing in the ID of the pathway, the API will return all the interactions within the pathway. http://www.pathwayapi.com/api/API_GetPathwayInteractions.php?
Negative_regulation (/) of api
2) Confidence 0.38 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0
After removal of AAP, secretion of urea and albumin returned to control levels.
Negative_regulation (removal) of AAP associated with paracetamol
3) Confidence 0.28 Published 2007 Journal ALTEX Section Abstract Doc Link 17361319 Disease Relevance 0.09 Pain Relevance 0.87
Decreases of plasminogen, Fg, AAP & ELT were found from 1 hr after therapy and persisted to 24, 12, 24 & 12 hr, respectively, with the maximum decrease usually between 1-4 hr.
Negative_regulation (Decreases) of AAP
4) Confidence 0.25 Published 1990 Journal Thromb. Res. Section Abstract Doc Link 1693793 Disease Relevance 0.29 Pain Relevance 0.08
Hypercoagulable states improve through decreased platelet aggregation and adhesion, increased plasminogen activator, increased plasmin, increased antithrombin III, decreased fibrinogen, decreased alpha 2-antiplasmin, decreased alpha 1-antitrypsin, and decreased alpha 2-macroglobulin.
Negative_regulation (decreased) of alpha 2-antiplasmin in platelet associated with adhesions
5) Confidence 0.21 Published 1994 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 8157787 Disease Relevance 0.94 Pain Relevance 0.07
Passing in the ID of the pathway, the API will return all the interactions within the pathway. http://www.pathwayapi.com/api/API_GetPathwayInteractions.php?
Negative_regulation (/) of API
6) Confidence 0.18 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0
Whereas cLUK significantly decreased plasma levels of alpha 2-antiplasmin, plasminogen and fibrinogen, cPUK caused only a marginal decrease in alpha 2-antiplasmin and left the plasminogen and fibrinogen levels unchanged.
Negative_regulation (decrease) of 2-antiplasmin in plasma
7) Confidence 0.13 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
Fibrinolytic activity of cLUK was accompanied by a decrease in alpha 2-antiplasmin, plasminogen and fibrinogen.
Negative_regulation (decrease) of 2-antiplasmin
8) Confidence 0.13 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
One study suggested that strains possessing CVD432 and EAST-1 virulence markers are most commonly associated with chronic diarrhea in children [60]; whereas another study suggested that strains possessing aggR, aap, and astA (which encodes for EAST-1 protein) are most commonly associated with acute diarrhea in adults [61].
Negative_regulation (possessing) of aap associated with diarrhoea and sprains and strains
9) Confidence 0.12 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2837894 Disease Relevance 0.44 Pain Relevance 0
Whereas cLUK significantly decreased plasma levels of alpha 2-antiplasmin, plasminogen and fibrinogen, cPUK caused only a marginal decrease in alpha 2-antiplasmin and left the plasminogen and fibrinogen levels unchanged.
Negative_regulation (decreased) of 2-antiplasmin in plasma
10) Confidence 0.10 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
In contrast, cPUK did not change the plasminogen and fibrinogen levels and induced a substantially smaller decline in alpha 2-antiplasmin than cLUK.
Negative_regulation (decline) of 2-antiplasmin
11) Confidence 0.10 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3118890 Disease Relevance 0 Pain Relevance 0
Hematological tests show: mild anemia with leucocytosis; prolonged PT, PTT and ThT; decreased fibrinogen, factor V, factor XIII, plasminogen and alpha2-antiplasmin levels; increased factor VIII:c, von Willebrand factor, and FDPs/D-dimers levels with normal ATIII and platelets.
Negative_regulation (decreased) of alpha2-antiplasmin in platelets associated with anaemia
12) Confidence 0.00 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.72 Pain Relevance 0.14

General Comments

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