INT144051

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.46
Pain Relevance 3.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1) signal transducer activity (PTGER1)
Anatomy Link Frequency
macrophages 4
blood 2
spinal cord 2
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 99.98 Very High Very High Very High
hyperexcitability 2 99.90 Very High Very High Very High
Inflammation 44 99.84 Very High Very High Very High
Acute pain 3 99.20 Very High Very High Very High
Spinal cord 6 99.08 Very High Very High Very High
agonist 11 98.08 Very High Very High Very High
Dismenorea 1 97.32 Very High Very High Very High
rheumatoid arthritis 26 95.48 Very High Very High Very High
Pain 100 93.68 High High
nociceptor 5 92.60 High High
Disease Link Frequency Relevance Heat
Stress 2 99.98 Very High Very High Very High
INFLAMMATION 54 99.84 Very High Very High Very High
Pain 131 99.20 Very High Very High Very High
Fever 1 97.96 Very High Very High Very High
Dysmenorrhea 1 97.32 Very High Very High Very High
Rheumatoid Arthritis 26 95.48 Very High Very High Very High
Low Back Pain 2 90.16 High High
Arthritis 14 84.04 Quite High
Inflammatory Pain 7 79.72 Quite High
Death 5 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the spinal cord, prostaglandin-induced hyperexcitability was enhanced by EP1 receptors but reduced by an EP3?
Positive_regulation (enhanced) of Gene_expression (receptors) of EP1 in spinal cord associated with hyperexcitability and spinal cord
1) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.97 Pain Relevance 1.40
Microarray analysis revealed that inflammatory stress increases expression of synthases and receptors for prostaglandin E2 (PGE(2)) and prostaglandin F2?
Positive_regulation (increases) of Gene_expression (expression) of PGE associated with stress and inflammation
2) Confidence 0.07 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20839316 Disease Relevance 0.46 Pain Relevance 0.36
This study was aimed to investigate the inhibitory mechanism of HA on lipopolysaccharide (LPS)-stimulated PGE(2) production in U937 human macrophages.
Positive_regulation (stimulated) of Gene_expression (production) of PGE in macrophages
3) Confidence 0.06 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.58 Pain Relevance 0.37
Anti-CD44 antibody reversed the inhibitory effects of HA on the LPS-mediated increase in PGE(2) production, COX-2 induction, and activation of NF-kappaB.
Positive_regulation (increase) of Gene_expression (production) of PGE
4) Confidence 0.06 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.25 Pain Relevance 0.27
Stimulation of U937 macrophages with LPS enhanced PGE(2) production in association with increased protein levels of cyclooxygenase-2 (COX-2).
Positive_regulation (enhanced) of Gene_expression (production) of PGE in macrophages
5) Confidence 0.06 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.56 Pain Relevance 0.36
Specifically in response to TNF-alpha, TGF-beta, and LPS, protein expression of cyclooxygenase (COX)-2 and downstream PGE synthase was up-regulated with coordinate kinetics, whereas COX-1 and PGIS were constitutively expressed.
Positive_regulation (up-regulated) of Gene_expression (expression) of PGE synthase
6) Confidence 0.05 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18209033 Disease Relevance 0.26 Pain Relevance 0.03
Anti-CD44 antibody reversed the inhibitory effects of HA on the LPS-mediated increase in PGE(2) production, COX-2 induction, and activation of NF-kappaB.
Positive_regulation (induction) of Gene_expression (production) of PGE
7) Confidence 0.05 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.25 Pain Relevance 0.27
Anti-CD44 antibody reversed the inhibitory effects of HA on the LPS-mediated increase in PGE(2) production, COX-2 induction, and activation of NF-kappaB.
Positive_regulation (increase) of Gene_expression (production) of PGE
8) Confidence 0.05 Published 2010 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 20208419 Disease Relevance 0.25 Pain Relevance 0.27
In LPS-stimulated whole blood, AF3442 inhibited in a concentration-dependent fashion inducible PGE(2) biosynthesis with an IC(50) of 29microM.
Positive_regulation (inducible) of Gene_expression (biosynthesis) of PGE in blood
9) Confidence 0.04 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19925781 Disease Relevance 0.11 Pain Relevance 0.05
During parturition, inflammatory cytokines promote PGE(2) production through increased prostaglandin-endoperoxide synthase-2 (PTGS2, also known as cyclooxygenase-2) expression.
Positive_regulation (promote) of Gene_expression (production) of PGE associated with inflammation and cytokine
10) Confidence 0.03 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.20 Pain Relevance 0.26
The microsomal (m)PGES-1 isoform serves as an inducible PGES and is responsible for the production of PGE(2), which mediates acute pain in inflammation and fever.
Positive_regulation (responsible) of Gene_expression (production) of PGE associated with inflammation, acute pain and fever
11) Confidence 0.03 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.57 Pain Relevance 0.33

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