INT144057

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 7.94
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
Anatomy Link Frequency
SCN 3
platelet 1
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 21 100.00 Very High Very High Very High
fluoxetine 19 99.48 Very High Very High Very High
sSRI 4 85.92 High High
antidepressant 6 85.52 High High
Neuropeptide 9 84.60 Quite High
depression 3 62.24 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Failure 198 100.00 Very High Very High Very High
Platelet Disorder 1 99.34 Very High Very High Very High
Thrombocytopenia 1 98.92 Very High Very High Very High
Coagulation Disorder 1 98.00 Very High Very High Very High
Anxiety Disorder 8 96.36 Very High Very High Very High
Disease 83 94.72 High High
Aging 17 93.56 High High
Hemorrhage 8 93.52 High High
Congenital Anomalies 1 90.32 High High
Syndrome 42 76.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with a history of coagulation disorders, especially suspected or documented thrombocytopenia or platelet disorder, should be monitored in case of prescription of any serotonin reuptake inhibitor (SRI).
Transcription (prescription) of SRI in platelet associated with platelet disorder, thrombocytopenia and serotonin
1) Confidence 0.67 Published 2007 Journal Dialogues in clinical neuroscience Section Abstract Doc Link 17506225 Disease Relevance 1.25 Pain Relevance 0.56
SRI-SS: SRI summary score;
Transcription (score) of SRI-SS associated with respiratory failure
2) Confidence 0.41 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 2.90 Pain Relevance 0
SRI-SS: SRI summary score;
Transcription (score) of SRI associated with respiratory failure
3) Confidence 0.41 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 2.89 Pain Relevance 0
Because serotonin innervation trophically supports SCN VIP mRNA expression, and serotonin transporters decrease extracellular serotonin, we predicted that chronic administration of the serotonin-selective reuptake inhibitor, fluoxetine, would attenuate the age-related changes in SCN VIP mRNA expression and 5-HT(1B) receptors.
Transcription (expression) of SCN in SCN associated with serotonin and fluoxetine
4) Confidence 0.03 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525077 Disease Relevance 0.30 Pain Relevance 0.68
In situ hybridization studies showed that fluoxetine treatment does not alter SCN VIP mRNA expression, in either age group, at zeitgeber time (ZT)6 or 13 (ZT12 corresponds to lights off).
Transcription (expression) of SCN in SCN associated with fluoxetine
5) Confidence 0.03 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525077 Disease Relevance 0.36 Pain Relevance 0.73
Because serotonin innervation trophically supports SCN VIP mRNA expression, and serotonin transporters decrease extracellular serotonin, we predicted that chronic administration of the serotonin-selective reuptake inhibitor, fluoxetine, would attenuate the age-related changes in SCN VIP mRNA expression and 5-HT(1B) receptors.
Transcription (expression) of SCN in SCN associated with serotonin and fluoxetine
6) Confidence 0.03 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525077 Disease Relevance 0.25 Pain Relevance 0.63

General Comments

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