INT144069

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) peptidase activity (MMP1) transport (TRPV1)
extracellular region (MMP1) proteinaceous extracellular matrix (MMP1) plasma membrane (TRPV1)
Anatomy Link Frequency
keratinocytes 3
TRPV1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 18 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 16 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased MMP-1 expression.
Positive_regulation (activation) of TRPV1 Positive_regulation (increased) of Gene_expression (expression) of MMP-1 associated with qutenza, metalloproteinase and agonist
1) Confidence 0.43 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.69 Pain Relevance 0.53
Taken together, our results suggest that heat-shock-induced MMP-1 expression is mediated by activation of TRPV1 and is dependent on a calcium-dependent signaling process in human epidermal keratinocytes.
Positive_regulation (activation) of TRPV1 in keratinocytes Positive_regulation (mediated) of Gene_expression (expression) of MMP-1 in keratinocytes associated with shock and metalloproteinase
2) Confidence 0.43 Published 2007 Journal J. Invest. Dermatol. Section Abstract Doc Link 17508023 Disease Relevance 0.66 Pain Relevance 0.50

General Comments

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