INT144073

Context Info Confidence 0.24 First Reported 2007 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 5 Disease Relevance 6.13 Pain Relevance 0.72

cytoplasm (MMP14)

Anatomy Link Frequency colon 2 keratinocytes 2 MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 61 100.00 qutenza 3 98.78 agonist 1 57.08 cytokine 2 8.88 chemokine 3 8.44 Inflammation 15 5.00 rheumatoid arthritis 7 5.00 Multiple sclerosis 4 5.00 palliative 3 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Shock 8 99.98 Prostate Cancer 106 99.84 Metastasis 78 99.80 Osteolysis 12 99.28 Carcinoma 4 99.28 Cancer 95 96.64 Malignant Neoplastic Disease 5 94.64 Brain Tumor 2 94.24 Skin Cancer 5 93.28 Aggression 3 77.40

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MMP-14 expression is elevated in various human carcinomas including uterine cervix [93], stomach [94], lung [95–97], breast [98], colon [99], head and neck [100], malignant brain tumors [101], and melanoma [102].

Positive_regulation (elevated) of Gene_expression (expression) of MMP-14 in colon associated with malignant neoplastic disease, carcinoma, skin cancer and brain tumor

1) Confidence 0.24 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.61 Pain Relevance 0.15

Alternatively, the bone microenvironment might induce the expression of mt1-mmp in prostate cancer cells after their arrival in the marrow.

Spec (might) Positive_regulation (induce) of Gene_expression (expression) of mt1-mmp associated with prostate cancer

2) Confidence 0.20 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.40 Pain Relevance 0

Compared with controls, tibiae injected with LNCaP cells overexpressing mt1-mmp showed increased osteolysis (as demonstrated by radiography and histomorphometry) and enhanced intraosseous tumour growth.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of mt1-mmp associated with cancer and osteolysis

3) Confidence 0.20 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.26 Pain Relevance 0

We overexpressed mt1-mmp in LNCaP human prostate cancer cells (which have baseline non-detectable expression of the protease), while its expression was attenuated in DU145 cells (which have baseline high mt1-mmp expression) using small interfering rna.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of mt1-mmp associated with prostate cancer

4) Confidence 0.20 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.36 Pain Relevance 0

Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes.

Positive_regulation (induced) of Gene_expression (expression) of matrix metalloproteinase-1 in keratinocytes associated with qutenza, shock and metalloproteinase

5) Confidence 0.12 Published 2007 Journal J. Invest. Dermatol. Section Title Doc Link 17508023 Disease Relevance 0.50 Pain Relevance 0.57

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