INT144083

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 8.16
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccl3) extracellular space (Ccl3) extracellular region (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
macrophages 8
microglia 2
T-cell 2
Kupffer cell 2
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 416 100.00 Very High Very High Very High
Inflammation 292 100.00 Very High Very High Very High
cytokine 70 100.00 Very High Very High Very High
Central nervous system 261 95.04 Very High Very High Very High
opioid receptor 1 93.04 High High
Angina 4 90.60 High High
Cannabinoid 1 90.16 High High
ischemia 4 88.08 High High
Inflammatory mediators 15 82.00 Quite High
Inflammatory response 32 76.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 344 100.00 Very High Very High Very High
Acute Disease 10 100.00 Very High Very High Very High
Myocardial Infarction 6 99.72 Very High Very High Very High
Recurrence 80 99.68 Very High Very High Very High
Multiple Sclerosis 395 99.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 57 98.00 Very High Very High Very High
Acute Coronary Syndrome 3 97.68 Very High Very High Very High
Togavirus Infection 75 96.72 Very High Very High Very High
Central Nervous System Disease 240 95.04 Very High Very High Very High
Colitis 5 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore circulating levels of CCL3 were significantly enhanced after AMI in mice (P=0.02), while CCR5(+) T-cell numbers were increased as well, suggestive of CCL3 driven T-cell homing towards the ischemic area.
Positive_regulation (enhanced) of Gene_expression (levels) of CCL3 in T-cell associated with myocardial infarction
1) Confidence 0.50 Published 2008 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 18619972 Disease Relevance 1.29 Pain Relevance 0.61
Significant increases in cytokines, such as interleukin (IL)-1beta, IL-6 and granulocyte macrophage colony stimulating factor (GM-CSF), and in chemokines, such as macrophage chemotactic protein 1 (MCP-1), macrophage inflammatory protein 1 (MIP-1alpha) and Kupffer cell derived chemokine (KC), were detected, with no changes in T-cell-derived cytokines.
Positive_regulation (increases) of Neg (no) Gene_expression (detected) of MIP-1alpha in Kupffer cell associated with chemokine, inflammation and cytokine
2) Confidence 0.49 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.57 Pain Relevance 0.72
(CCL3) expression correlates with the severity of acute disease and also is elevated during relapses in CR-EAE.
Positive_regulation (elevated) of Gene_expression (expression) of CCL3 associated with multiple sclerosis, acute disease and recurrence
3) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.58 Pain Relevance 0.31
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Gene_expression (genes) of Ccl3 associated with chemokine
4) Confidence 0.40 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.89 Pain Relevance 0.62
Additional studies demonstrated the expression of CCL3 and CCL4 in macrophages and microglia, and CCL3 also in astrocytes [47-49].
Positive_regulation (demonstrated) of Gene_expression (expression) of CCL3 in macrophages
5) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.32 Pain Relevance 0.22
Additional studies demonstrated the expression of CCL3 and CCL4 in macrophages and microglia, and CCL3 also in astrocytes [47-49].
Positive_regulation (demonstrated) of Gene_expression (expression) of CCL3 in macrophages
6) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.31 Pain Relevance 0.22
Moreover, increased expression of the CCR5 ligand, MIP-1a/CCL3, in humans (as a result of gene duplication) provides protection from HIV acquisition (Gonzalez et al 2005).
Positive_regulation (increased) of Gene_expression (expression) of CCL3 associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.18 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.55 Pain Relevance 0.20
Engagement of various TLRs by specific PAMPs leads to production and release of cytokines
         (such as TNF and the interleukins IL- 1 and IL-6) and chemokines (such as IL-8, and the
         ‘macrophage inflammatory proteins’ CCL3 and CCL4) (Ref. 12). 
Positive_regulation (leads) of Gene_expression (production) of CCL3 in macrophage associated with chemokine, inflammation and cytokine
8) Confidence 0.14 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.01 Pain Relevance 0.46
Additional studies demonstrated the expression of CCL3 and CCL4 in macrophages and microglia, and CCL3 also in astrocytes [47-49].
Positive_regulation (demonstrated) of in microglia Gene_expression (expression) of CCL3 in macrophages
9) Confidence 0.10 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.31 Pain Relevance 0.22
Additional studies demonstrated the expression of CCL3 and CCL4 in macrophages and microglia, and CCL3 also in astrocytes [47-49].
Positive_regulation (demonstrated) of in microglia Gene_expression (expression) of CCL3 in macrophages
10) Confidence 0.10 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.32 Pain Relevance 0.22

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