INT144087

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 1.23
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm7) plasma membrane (Trpm7) kinase activity (Trpm7)
transmembrane transport (Trpm7) cytoplasm (Trpm7)
Anatomy Link Frequency
leukocyte 1
neurons 1
brain 1
Trpm7 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 1 99.60 Very High Very High Very High
chemokine 3 97.92 Very High Very High Very High
cytokine 8 97.36 Very High Very High Very High
opioid receptor 1 96.88 Very High Very High Very High
Potency 44 94.96 High High
Action potential 11 82.84 Quite High
imagery 66 80.80 Quite High
ischemia 55 75.56 Quite High
Neuropeptide 3 75.00 Quite High
antagonist 33 73.56 Quite High
Disease Link Frequency Relevance Heat
Colitis 5 92.88 High High
Epilepsy 33 81.92 Quite High
Cv Unclassified Under Development 33 75.56 Quite High
Brain Hemorrhage 22 73.88 Quite High
INFLAMMATION 14 62.32 Quite High
Sprains And Strains 17 54.48 Quite High
Pain 13 31.68 Quite Low
Death 23 5.00 Very Low Very Low Very Low
Stress 11 5.00 Very Low Very Low Very Low
Coronary Heart Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DAPI and HSB but not netropsin, blocked and stimulated TRPM7.
Positive_regulation (stimulated) of TRPM7
1) Confidence 0.69 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.12 Pain Relevance 0.03
In the presence of physiological concentrations of extracellular divalent cations, NM activates TRPM7.
Positive_regulation (activates) of TRPM7
2) Confidence 0.69 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.14 Pain Relevance 0.03
NM also activates TRPM7 currents?
Positive_regulation (activates) of TRPM7
3) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
Unexpectedly, pre-exposure to NM strongly potentiated TRPM7 currents.
Positive_regulation (potentiated) of TRPM7
4) Confidence 0.50 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3022637 Disease Relevance 0.15 Pain Relevance 0.04
Figure 4C shows that a brief NM-washout lead to an enhancement of TRPM7 currents that was subsequently suppressed when NM was re-introduced (n = 5), indicating the NM-activated current is blocked by NM.
Positive_regulation (enhancement) of TRPM7
5) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0
NM inhibits TRPM7-induced increases in intracellular Ca2+ in cultured hippocampal and cortical neurons
Positive_regulation (increases) of TRPM7 in neurons
6) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
Furthermore, an enhancement of TRPM7 currents by NM was also observed (Figure 6C, D &6E).


Positive_regulation (enhancement) of TRPM7
7) Confidence 0.50 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.08
Voltage ramps were employed to evoke currents from over-expressed TRPM7 channels induced in HEK293T cells.
Positive_regulation (induced) of TRPM7
8) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.11
The diffusion barriers presented in the slice preparation preclude very rapid changes in divalent cation concentrations but prolonged solution changes can be used to activate TRPM7 currents in this preparation [19].
Positive_regulation (activate) of TRPM7
9) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0
However, the ability of NM to compete with divalents for TRPM7 currents would also potentially predispose activation of TRPM7 currents resulting in enhancement of the currents.
Positive_regulation (activation) of TRPM7
10) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.22 Pain Relevance 0.04
In this situation they might be anticipated to block TRPM7 currents and therefore reduce the deleterious effects of an influx of Ca2+ and provide a unique mechanism that targets the inappropriate activation of TRPM7 channels.
Positive_regulation (activation) of TRPM7
11) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.23 Pain Relevance 0.04
In most brain areas the copy number of TRPM3 mRNA exceeded even that of TRPM7.
Positive_regulation (exceeded) of TRPM7 in brain
12) Confidence 0.41 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.05 Pain Relevance 0
Significant increases in neuronal receptors, such as transient receptor potential A1 (TRPA1), cannabinoid type 1 receptor, neurokinin 1 receptor (NK1R) and delta-opioid receptor; prokineticin-1 receptor; and soluble mediators, such as prodynorphin, proenkephalin1, NK1, prokineticin-1 and secretory leukocyte protease inhibitor, occurred.
Positive_regulation (increases) of transient receptor potential A1 in leukocyte associated with cannabinoid and opioid receptor
13) Confidence 0.19 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17509021 Disease Relevance 0.31 Pain Relevance 0.47

General Comments

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