INT144095

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.50
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
blood 1
cardiomyocyte 1
endothelial cells 1
lung 1
pit 1
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Cholecystokinin 2 100.00 Very High Very High Very High
Inflammatory response 9 95.20 Very High Very High Very High
withdrawal 3 76.56 Quite High
metalloproteinase 6 71.92 Quite High
ischemia 1 65.16 Quite High
Tetrahydrobiopterin 7 58.60 Quite High
alcohol 3 50.08 Quite High
Inflammation 61 50.00 Quite Low
cytokine 48 50.00 Quite Low
Thermal hyperalgesia 18 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 118 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 137 99.28 Very High Very High Very High
Insulin Resistance 14 99.20 Very High Very High Very High
Injury 73 95.58 Very High Very High Very High
Stress 36 94.88 High High
INFLAMMATION 80 94.84 High High
Hypertension 31 91.48 High High
Hyperlipidemia 4 90.16 High High
Hyperphagia 1 88.72 High High
Pressure Volume 2 Under Development 2 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the increased eNOS activity present in the female mouse lung might lead to the increased GSNO-R activity as a counter-regulatory mechanism to minimize nitrosative stress.
Localization (present) of eNOS in lung associated with stress
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 0.22 Pain Relevance 0.03
In mice, eNOS (endothelial nitric oxide synthase) maintains in vivo pancreatic secretory responses to carbachol or cholecystokinin octapeptide (CCK-8), maintains insulin sensitivity, and modulates pancreatic microvascular blood flow (PMBF). eNOS(-/-) mice are insulin resistant, and their exocrine pancreatic secretion is impaired.
Localization (secretion) of endothelial nitric oxide synthase in blood associated with cholecystokinin
2) Confidence 0.52 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510194 Disease Relevance 0.23 Pain Relevance 0.05
In addition, the same tissue was also dissected out from nNOS-, iNOS-, and eNOS-KO mice at 24 h after NS injection (NOS-KO control groups), and at 6, 16 and 24 h after CFA (NOS-KO CFA groups).
Localization (dissected) of eNOS associated with targeted disruption
3) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.49 Pain Relevance 0.11
Pioglitazone reverses insulin resistance and impaired CCK-stimulated pancreatic secretion in eNOS(-/-) mice: therapy for exocrine pancreatic disorders?
Localization (secretion) of eNOS associated with insulin resistance
4) Confidence 0.49 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17510194 Disease Relevance 0.25 Pain Relevance 0.05
Data from our lab
               revealed that leptin directly suppresses cardiomyocyte contraction and intracellular
                   Ca2+ handling through mechanism(s) related to endothelial
               nitric oxide synthase (eNOS), superoxide (O2?)
               
Localization (related) of eNOS in cardiomyocyte
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.14 Pain Relevance 0
Consistent with this idea is the observation that HDL maintains the appropriate cellular localization of eNOS by replenishing endothelial cellular membranes with cholesteryl esters in an SR-BIĀ–dependent fashion (Uittenbogaard et al 2000).
Localization (localization) of eNOS associated with disorder of lipid metabolism
6) Confidence 0.40 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.90 Pain Relevance 0.06
The source of this superoxide is likely the NADPH oxidase that is co-localized with eNOS in subcellular compartments within endothelial cells [51].
Localization (localized) of eNOS in endothelial cells
7) Confidence 0.23 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.58 Pain Relevance 0.10
There are three types of NO synthase (NOS): neural NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). nNOS and eNOS are constitutively expressed, whereas iNOS is induced upon gastric injury [35]. nNOS was distributed similarly to the PAS-staining over the foveolar pit region (Figure 1g); it was observed over the elongated pit of the TG mucosa and was limited to the luminal pit of the WT mucosa (Figure 4a). eNOS was weakly scattered over the entire gastric mucosa similarly in both the WT and TG mucosae (data not shown).
Localization (scattered) of eNOS in pit associated with targeted disruption and injury
8) Confidence 0.20 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.71 Pain Relevance 0.03

General Comments

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