INT144097

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
Hypism (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 70.32 Quite High
tolerance 6 62.08 Quite High
Intracerebroventricular 8 60.48 Quite High
agonist 2 59.60 Quite High
Central nervous system 2 58.84 Quite High
Cholecystokinin 1 57.88 Quite High
Endocannabinoid 8 53.88 Quite High
cannabis 1 31.84 Quite Low
Neuropeptide 1 18.56 Low Low
depression 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 30 100.00 Very High Very High Very High
Hyperglycemia 6 99.72 Very High Very High Very High
Obesity 108 99.56 Very High Very High Very High
Impaired Glucose Tolerance 7 99.28 Very High Very High Very High
Metabolic Syndrome 127 98.84 Very High Very High Very High
Overweight 26 98.36 Very High Very High Very High
Congenital Anomalies 10 92.80 High High
Insulin Resistance 27 89.96 High High
Osteoporosis 14 85.72 High High
Diabetes Mellitus 47 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pioglitazone abolished the CCK-8-evoked hyperinsulinemia (P < 0.005) and increased insulin sensitivity of eNOS(-/-) mice (P < 0.05), the latter based on hyperinsulinemic-euglycemic clamp studies.
Negative_regulation (abolished) of hyperinsulinemia associated with hyperinsulinism
1) Confidence 0.18 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510194 Disease Relevance 0.65 Pain Relevance 0.13
Accordingly, Esp inactivation doubles hyperinsulinemia and delays glucose intolerance in ob/ob mice, whereas Osteocalcin inactivation halves their hyperinsulinemia.
Negative_regulation (inactivation) of hyperinsulinemia associated with obesity, hyperinsulinism and impaired glucose tolerance
2) Confidence 0.13 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2606962 Disease Relevance 0.64 Pain Relevance 0
mice displayed a hyperinsulinemia and lower blood glucose level after feeding (Fig. 2, K and L).
Negative_regulation (displayed) of hyperinsulinemia in blood associated with hyperinsulinism
3) Confidence 0.13 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.66 Pain Relevance 0.09
Hyperglycemia follows when hyperinsulinemia cannot be maintained due to a failure of insulin production (Reaven 2005).
Negative_regulation (maintained) of hyperinsulinemia associated with hyperglycemia and hyperinsulinism
4) Confidence 0.01 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 0.93 Pain Relevance 0.08

General Comments

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