INT144098

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.73
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 4 99.90 Very High Very High Very High
agonist 5 89.04 High High
Cholecystokinin 1 81.48 Quite High
Chronic pancreatitis 1 28.80 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 2 99.22 Very High Very High Very High
Disease 2 96.64 Very High Very High Very High
Insulin Resistance 5 93.92 High High
Hyperinsulinism 2 59.76 Quite High
Diabetes Mellitus 1 31.28 Quite Low
Pancreatitis 1 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this hypothesis, we gave eNOS(-/-) and wild-type (WT) mice pioglitazone (20 or 50 mg.kg(-1).day(-1)), an insulin-sensitizing peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activator, and measured pancreatic protein secretion evoked by CCK-8 (160 pmol.kg(-1).h(-1), a maximal stimulus).
Localization (secretion) of peroxisome proliferator-activated receptor-gamma
1) Confidence 0.59 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510194 Disease Relevance 0.38 Pain Relevance 0.04
The modulation of both targets with approved drugs (i.e., amyloid-beta 42 (Abeta42)-lowering NSAIDs for gamma-secretase and glitazones for PPARgamma) has demonstrated beneficial effects in in vitro and in vivo models of Alzheimer's disease (AD).
Localization (gamma-secretase) of PPARgamma associated with alzheimer's dementia, cinod and disease
2) Confidence 0.53 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20503989 Disease Relevance 0.20 Pain Relevance 0.27
We present a novel class of dual modulators of gamma-secretase and peroxisome proliferator-activated receptor gamma (PPARgamma) based on the structure of 2-(bis(phenethoxy)pyrimidine-2-ylthio)hexanoic acid 8 (IC(50)(Abeta42) = 22.8 microM, EC(50)(PPARgamma) = 8.3 microM).
Localization (gamma-secretase) of PPARgamma
3) Confidence 0.53 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20503989 Disease Relevance 0.15 Pain Relevance 0.21

General Comments

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