INT144100

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.65
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
Blood vessel 2
leukocyte 1
Pecam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 71 87.68 High High
anesthesia 4 86.64 High High
isoflurane 4 86.20 High High
Arthritis 33 48.08 Quite Low
cytokine 9 44.24 Quite Low
Osteoarthritis 9 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 8 99.58 Very High Very High Very High
Cancer 342 99.36 Very High Very High Very High
Colitis 9 97.28 Very High Very High Very High
Urological Neuroanatomy 4 90.44 High High
Adhesions 9 90.08 High High
Disease 37 88.80 High High
Melanoma 7 87.28 High High
INFLAMMATION 78 86.60 High High
Corneal Neovascularization 7 86.44 High High
Infection 4 76.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of this study was to determine the role of PECAM-1 in experimental IBD and to show whether blockade of PECAM-1 has therapeutic effects.
Spec (whether) Negative_regulation (blockade) of PECAM-1 associated with inflammatory bowel disease
1) Confidence 0.59 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510197 Disease Relevance 0.88 Pain Relevance 0.19
Immunoblockade of PECAM-1 reduced leukocyte transmigration significantly and also diminished leukocyte rolling and sticking in an indirect manner.
Negative_regulation (Immunoblockade) of PECAM-1 in leukocyte
2) Confidence 0.43 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17510197 Disease Relevance 0.97 Pain Relevance 0.23
To examine the effect of endothelial Rac1-depletion on tumor angiogenesis, blood vessel density was quantified by counting the numbers of PECAM-1+/GFP?
Negative_regulation (numbers) of PECAM in blood vessel associated with cancer
3) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.97 Pain Relevance 0
Blood vessel density in immunofluorescent stained sections from size-matched tumors was determined by counting the number of PECAM-1+/GFP?
Negative_regulation (number) of PECAM in Blood vessel associated with cancer
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.15 Pain Relevance 0
Detection of PECAM1 staining was completed using the tyramide amplification system according to the manufacturer's instructions (PerkinElmer, Boston, MA).
Negative_regulation (Detection) of PECAM1
5) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.55 Pain Relevance 0
Consistently, the fractional CD31 area was significantly decreased after therapy whereas the aSMA area was not modified (Table 3).
Negative_regulation (decreased) of CD31
6) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0.13 Pain Relevance 0

General Comments

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