INT144107

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC6A2, SLC6A4) cytosol (SLC6A4) endosome (SLC6A4)
transport (SLC6A2) transmembrane transport (SLC6A2)
SLC6A2 (Homo sapiens)
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 4 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Potency 1 100.00 Very High Very High Very High
agonist 1 94.36 High High
spastic colon 1 91.00 High High
Spinal nerve ligature 1 76.48 Quite High
Neuropathic pain 1 72.64 Quite High
Disease Link Frequency Relevance Heat
Functional Bowel Disorder 1 91.00 High High
Constipation 1 89.52 High High
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Numerous compounds (e.g., 19-22) had low nonamolar hNET potency with IC(50) values of 7-10 nM and excellent selectivity (>500 fold) at hNET over hSERT and hDAT.
hNET Binding (potency) of hSERT associated with potency
1) Confidence 0.00 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19722525 Disease Relevance 0 Pain Relevance 0.30
It is unknown, however, whether tegaserod interacts with the human serotonin reuptake transporter (hSERT) and the uptake transporters for dopamine (hDAT) and norepinephrine (hNET).
hNET Spec (whether) Binding (interacts) of hSERT associated with dopamine and serotonin
2) Confidence 0.00 Published 2007 Journal Digestion Section Abstract Doc Link 17510552 Disease Relevance 0.18 Pain Relevance 0.32

General Comments

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