INT144110

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.38
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PRSS1, IL8) extracellular region (PRSS1, IL8) signal transduction (IL8)
peptidase activity (PRSS1) intracellular (IL8)
Anatomy Link Frequency
epithelial cells 2
PRSS1 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 99.78 Very High Very High Very High
Inflammation 6 97.16 Very High Very High Very High
nociceptor 2 93.36 High High
Neuropeptide 1 86.24 High High
substance P 1 84.48 Quite High
cytokine 4 82.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 97.88 Very High Very High Very High
Esophageal Disease 1 96.32 Very High Very High Very High
Dyspepsia 3 89.56 High High
Disease 1 89.32 High High
Gastroesophageal Reflux Disease 4 87.84 High High
Stress 1 83.88 Quite High
Neurogenic Inflammation 1 79.60 Quite High
Injury 1 76.52 Quite High
Hypersensitivity 1 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it has been shown that bile acids and trypsin can promote IL-8 production from human esophageal epithelial cells via NFkappaB-and AP-1-dependent mechanism.
trypsin Positive_regulation (promote) of Gene_expression (production) of IL-8 in epithelial cells associated with bile
1) Confidence 0.21 Published 2007 Journal Nippon Rinsho Section Abstract Doc Link 17511218 Disease Relevance 1.38 Pain Relevance 0.48

General Comments

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