INT144168

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Context Info
Confidence 0.13
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.69
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL1) extracellular space (CCL1) extracellular region (CCL1)
Anatomy Link Frequency
hip 1
CCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 77 100.00 Very High Very High Very High
Inflammation 73 100.00 Very High Very High Very High
cytokine 59 100.00 Very High Very High Very High
Inflammatory mediators 2 100.00 Very High Very High Very High
Pain 27 97.24 Very High Very High Very High
rheumatoid arthritis 153 89.84 High High
corticosteroid 2 85.60 High High
cva 7 79.36 Quite High
IPN 3 69.76 Quite High
Lamotrigine 4 57.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 84 100.00 Very High Very High Very High
Cancer 9 99.92 Very High Very High Very High
Syndrome 88 99.84 Very High Very High Very High
Necrosis 10 99.68 Very High Very High Very High
Adhesions 4 99.60 Very High Very High Very High
Fatigue 38 98.84 Very High Very High Very High
Disorders Of The Lacrimal System 61 98.60 Very High Very High Very High
Pain 11 97.24 Very High Very High Very High
Dacryocystitis 23 96.88 Very High Very High Very High
Body Weight 2 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCL8, CXCL12, CCL1 and CCL2) and other chemokines are angiostatic (e.g.
Gene_expression (angiostatic) of CCL1 associated with chemokine
1) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.35 Pain Relevance 0.56
The results indicate that the tissue-engineering substrate and the bioactive peptides modulate the initial U937 adhesion and the subsequent inflammatory cytokine gene and protein expression.
Gene_expression (expression) of inflammatory cytokine gene associated with inflammation, adhesions and cytokine
2) Confidence 0.10 Published 2007 Journal Tissue Eng. Section Abstract Doc Link 17518591 Disease Relevance 0.58 Pain Relevance 0.29
Others have shown that with increases in dose of EPA there is greater production of the anti-inflammatory cytokine IL-4 [21].
Gene_expression (production) of anti-inflammatory cytokine IL-4 associated with inflammation and cytokine
3) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.36 Pain Relevance 0.23
Aseptic loosening of hip prosthesis as it occurs in clinical cases in human patients was attributed to wear particles of the implants, the response of the tissue dominated by macrophages and the production of inflammatory mediators and matrix degrading enzymes; however, the cascade of events initiating the process and their interaction regarding the time course is still open and discussed controversially.
Gene_expression (production) of inflammatory in hip associated with inflammatory mediators
4) Confidence 0.02 Published 2004 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC404466 Disease Relevance 0.16 Pain Relevance 0.05
It was also found that the levels of the inflammatory cytokine, tumor necrosis factor, in the CSF were reduced after treatment.
Gene_expression (levels) of inflammatory cytokine associated with necrosis, inflammation, cancer and cytokine
5) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.42 Pain Relevance 0.40
Gonzales et al were the first researchers to show that IVIG reduced CSF inflammatory cytokine levels in PPS patients,41 and this observation provided the rationale for trying IVIG as a therapy in PPS.
Gene_expression (levels) of inflammatory cytokine associated with inflammation, syndrome and cytokine
6) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.27 Pain Relevance 0.42
Anti-inflammatory cytokine gene expression might offer a potential therapeutic modality for the treatment of autoimmune dacryoadenitis, once suitable vectors become available.



Gene_expression (expression) of Anti-inflammatory cytokine gene associated with inflammation, dacryocystitis and cytokine
7) Confidence 0.01 Published 2005 Journal J Autoimmune Dis Section Abstract Doc Link PMC1187915 Disease Relevance 1.28 Pain Relevance 0.10
Anti-inflammatory cytokine, IL-10 was found to be significantly raised in most of the patients (P<0.05).
Gene_expression (raised) of Anti-inflammatory cytokine associated with inflammation and cytokine
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.26 Pain Relevance 0.40

General Comments

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