INT144198

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.66
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HSPB2) nucleus (HSPB2) cytoplasm (HSPB2)
Anatomy Link Frequency
sensory neurons 1
HSPB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 78.72 Quite High
Pain 3 25.00 Low Low
metalloproteinase 14 21.08 Low Low
Angina 5 5.00 Very Low Very Low Very Low
diabetic neuropathy 5 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 105 99.76 Very High Very High Very High
Neuropathy 115 99.72 Very High Very High Very High
Reprotox - General 1 58 99.60 Very High Very High Very High
Diabetes Complications 25 99.40 Very High Very High Very High
Metastasis 43 99.12 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 35 99.08 Very High Very High Very High
Nicotine Addiction 15 82.40 Quite High
Cardiovascular Disease 35 81.88 Quite High
Peripheral Neuropathy 5 80.72 Quite High
INFLAMMATION 10 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After exercise (30 min), the ELISA analysis showed a 49 +/- 13% reduction of the HSP27 level in the cytosolic fraction (P < 0.01), whereas Western blotting revealed a 15-fold increase of the HSP27 level in the myofibrillar fraction (P < 0.01).
Positive_regulation (increase) of HSP27
1) Confidence 0.48 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17522120 Disease Relevance 0.21 Pain Relevance 0
Although sHSP27 levels were also slightly higher in case subjects with retinopathy (P = 0.06), this was mainly due to the confounding association with AER, as values became similar after further adjustment for AER (P = 0.57).
Positive_regulation (higher) of sHSP27 associated with ocular toxicity (including many sub-types)
2) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 1.10 Pain Relevance 0
Mean sHSP27 levels were significantly higher in case subjects with DSP than in control subjects, even after adjustment for age and AER.
Positive_regulation (higher) of sHSP27 associated with neuropathy
3) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 0.78 Pain Relevance 0.04
Consistent with this hypothesis, studies in experimental diabetes have shown HSP27 induction in the sensory neurons of the dorsal root ganglia (4,5).
Positive_regulation (induction) of HSP27 in sensory neurons associated with diabetes mellitus
4) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 1.26 Pain Relevance 0.04
To assess patterns of ORs across increasing HSP27 values, ORs were categorized by the quartile distribution in control subjects.
Positive_regulation (increasing) of HSP27
5) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2453614 Disease Relevance 0.42 Pain Relevance 0
RESULTS¬óMean sHSP27 levels were significantly higher in case subjects with distal symmetrical polyneuropathy (DSP) than in control subjects, even after adjustment for age and albumin excretion rate (AER) (785.9 vs. 574.7 pg/ml, P = 0.03).
Positive_regulation (higher) of sHSP27 associated with neuropathy
6) Confidence 0.38 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453614 Disease Relevance 1.19 Pain Relevance 0.03
HSP27 is upregulated in human prostate cancer progression [148] and regulates the structure and function of the actin cytoskeleton, which has important consequences for cell motility [149].
Positive_regulation (upregulated) of HSP27 associated with reprotox - general 1
7) Confidence 0.17 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.69 Pain Relevance 0

General Comments

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