INT14420

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2003
Negated 2
Speculated 8
Reported most in Abstract
Documents 12
Total Number 20
Disease Relevance 3.82
Pain Relevance 11.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ureter 1
muscle 1
spinal cord 1
nucleus 1
epithelium 1
Nka1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 120 100.00 Very High Very High Very High
qutenza 77 100.00 Very High Very High Very High
Calcitonin gene-related peptide 28 100.00 Very High Very High Very High
Neuropeptide 23 100.00 Very High Very High Very High
agonist 20 100.00 Very High Very High Very High
calcitonin gene related peptide 3 100.00 Very High Very High Very High
opiate 2 100.00 Very High Very High Very High
lidocaine 3 99.82 Very High Very High Very High
Catecholamine 1 99.50 Very High Very High Very High
tetrodotoxin 18 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 10 99.04 Very High Very High Very High
Neurogenic Inflammation 2 98.86 Very High Very High Very High
Ganglion Cysts 9 97.98 Very High Very High Very High
Epilepsy 9 95.92 Very High Very High Very High
Stress Incontinence 18 94.92 High High
Increased Venous Pressure Under Development 2 84.48 Quite High
Bronchospasm 5 82.96 Quite High
Targeted Disruption 5 75.00 Quite High
Pain 2 72.48 Quite High
Nociception 3 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of capsaicin, substance P (SP) and neurokinin A (NKA) on motor activity and vascular permeability was investigated in the rat lower urinary tract (bladder dome and neck, proximal urethra and ureters).
Spec (investigated) Regulation (effects) of NKA in dome associated with stress incontinence, qutenza and substance p
1) Confidence 0.45 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2442629 Disease Relevance 0.30 Pain Relevance 0.63
The effects of dorsal root stimulation and of substance P (SP), neurokinin A (NKA), and calcitonin gene-related peptide (CGRP) on the basal release of 9 endogenous amino acids, including glutamate (Glu) and aspartate (Asp), have been investigated using the rat spinal cord slice-dorsal root ganglion preparation and high-performance liquid chromatography with fluorimetric detection.
Spec (investigated) Regulation (effects) of NKA in spinal cord associated with ganglion cysts, dorsal root ganglion, glutamate, spinal cord, calcitonin gene-related peptide and substance p
2) Confidence 0.44 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1693954 Disease Relevance 0.09 Pain Relevance 0.59
We performed a unilateral electrical stimulation (7.5 Hz, 5 ms, 0.8-1.4 mA for 5 min) of the TG in rat, to induce a neurogenic inflammation in the peripheral trigeminal domain including the dura, looking for calcitonin gene related peptide (CGRP), substance P (SP) and neurokinin A (NKA) immunoreactivity (IR) in the caudal trigeminal nucleus (CTN) into which massive central trigeminal processes terminate.
Regulation (looking) of NKA in nucleus associated with calcitonin gene related peptide, inflammation, trigeminal ganglion, neurogenic inflammation and substance p
3) Confidence 0.44 Published 2001 Journal J. Chem. Neuroanat. Section Abstract Doc Link 11312057 Disease Relevance 1.17 Pain Relevance 1.05
Luminal lidocaine did not affect the secretory response to NKA.
Neg (not) Regulation (affect) of NKA associated with lidocaine
4) Confidence 0.39 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9655689 Disease Relevance 0 Pain Relevance 0.28
Firstly, the tissue content of NKA-, SP- and CGRP-like immunoreactivity (LI) was measured in the fundus, in the corpus, in the muscle layer and in the mucosa of corpus of control rats and rats pre-treated with systemic capsaicin, s.c. (50 mg/kg as newborn).
Regulation (content) of NKA in muscle associated with qutenza, calcitonin gene-related peptide and substance p
5) Confidence 0.35 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716741 Disease Relevance 0 Pain Relevance 1.17
The effects on mean arterial pressure (MAP) and heart rate (HR) of increasing doses (0.65-65 nmol/kg) of substance P (SP), neurokinin A (NKA), neurokinin B (NKB) and selective agonists for neurokinin receptors were measured after intravenous (i.v.) injection in urethane anaesthetized rats.
Regulation (effects) of NKA in heart associated with agonist and substance p
6) Confidence 0.32 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2482449 Disease Relevance 0 Pain Relevance 0.49
The current study was designed to characterize the functionally active tachykinin receptors involved in tachykinin-elicited contractions in the pig intravesical ureter, and to investigate the possible modulation exerted by the natural tachykinins substance P (SP) and neurokinin A (NKA) on the non-adrenergic non-cholinergic (NANC) excitatory ureteral neurotransmission.
Spec (possible) Regulation (modulation) of NKA in ureter associated with substance p
7) Confidence 0.18 Published 2001 Journal Neurourol. Urodyn. Section Abstract Doc Link 11385696 Disease Relevance 0 Pain Relevance 0.36
These data suggest, although indirectly, that CGRP and NKA could be involved in the pathogenesis of migraine attacks in juvenile migraine patients.
Regulation (involved) of NKA in juvenile associated with migraine
8) Confidence 0.16 Published 1995 Journal Cephalalgia Section Abstract Doc Link 8536297 Disease Relevance 1.35 Pain Relevance 0.63
The effects of capsaicin, substance P (SP) and neurokinin A (NKA) on motor activity and vascular permeability was investigated in the rat lower urinary tract (bladder dome and neck, proximal urethra and ureters).
Spec (investigated) Regulation (effects) of NKA in proximal associated with stress incontinence, qutenza and substance p
9) Confidence 0.15 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2442629 Disease Relevance 0.30 Pain Relevance 0.63
The effects of capsaicin, substance P (SP) and neurokinin A (NKA) on motor activity and vascular permeability was investigated in the rat lower urinary tract (bladder dome and neck, proximal urethra and ureters).
Spec (investigated) Regulation (effects) of NKA in neck associated with stress incontinence, qutenza and substance p
10) Confidence 0.15 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2442629 Disease Relevance 0.30 Pain Relevance 0.63
The present study was designed to clarify whether opioid neuronal systems are involved in the beneficial effects of tachykinins such as the neurokinin NK1 receptor agonist, substance P (SP), the neurokinin NK2 receptor agonist, neurokinin A (NKA), and the neurokinin NK3 receptor agonist, senktide, on the scopolamine-induced impairment of spontaneous alternation performance in mice.
Regulation (effects) of NKA in neuronal associated with agonist, opioid and substance p
11) Confidence 0.11 Published 1998 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 9819798 Disease Relevance 0 Pain Relevance 0.52
We examined the effect of exogenously administered tachykinins, neurokinin A (NKA), substance P (SP) and neurokinin B (NKB) on neurally mediated cholinergic bronchoconstrictor responses in guinea-pigs. 2.
Spec (examined) Regulation (effect) of NKA associated with substance p
12) Confidence 0.09 Published 1996 Journal J Auton Pharmacol Section Abstract Doc Link 8736430 Disease Relevance 0.08 Pain Relevance 0.25
In isolated perfused lungs, SR 48968 concentration (0.01-10 microM) dependently inhibited NKA-, [beta-Ala8]-NKA- and capsaicin-induced bronchoconstriction whereas CP 99994 (30 microM) had no effect on SP-, NKA-, [beta-Ala8]-NKA- and capsaicin-induced bronchoconstriction.
Neg (no) Regulation (effect) of NKA in lungs associated with qutenza and substance p
13) Confidence 0.09 Published 2003 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 14565542 Disease Relevance 0 Pain Relevance 0.93
The effects of CGRP, SP, and neurokinin A (NKA) have been examined on isolated cerebral arteries in vitro.
Regulation (effects) of NKA associated with substance p and calcitonin gene-related peptide
14) Confidence 0.08 Published 1995 Journal Cephalalgia Section Abstract Doc Link 8536296 Disease Relevance 0.08 Pain Relevance 0.79
The aim of the present study was to examine the role of neuropeptides, especially substance P (SP) and neurokinin A (NKA), in toluene diisocyanate (TDI)-induced airway hyperresponsiveness (AHR) to acetylcholine aerosols.
Spec (examine) Regulation (role) of NKA associated with neuropeptide and substance p
15) Confidence 0.07 Published 1996 Journal Lung Section Abstract Doc Link 8919432 Disease Relevance 0 Pain Relevance 0.28
MATERIALS AND METHODS: We examined the effects of sensory neuropeptides including substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), as well as capsaicin on cultured guinea pig tracheal goblet cells by measuring the rate of mucus discharge visually under a microscope and the release of 35SO4 radiolabeled mucin-like glycoconjugates.
Spec (examined) Regulation (effects) of NKA in goblet cells
16) Confidence 0.07 Published 1998 Journal Changgeng Yi Xue Za Zhi Section Body Doc Link 9849009 Disease Relevance 0 Pain Relevance 0
We studied the effects of neurokinin A (NKA) and neurokinin B (NKB), the mammalian-derived tachykinins, on the electrical and ion transport properties of canine tracheal epithelium.
Regulation (effects) of NKA in epithelium
17) Confidence 0.06 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 2833141 Disease Relevance 0 Pain Relevance 0
Tachykinins such as substance P (SP) and neurokinin A (NKA) acting on neurokinin (NK) receptors modulate the nonadrenergic noncholinergic (NANC) neurotransmission in the gastrointestinal tract of several species, but the information about the mouse small intestine is scanty.
Regulation (modulate) of NKA in small intestine associated with substance p
18) Confidence 0.04 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10600814 Disease Relevance 0.14 Pain Relevance 0.29
Pretreatment with both piroxicam and TTX totally abolished the SP and NKA response.
Regulation (response) of NKA associated with tetrodotoxin and substance p
19) Confidence 0.04 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9809803 Disease Relevance 0 Pain Relevance 0.78
The present results indicate that acetylcholine, carbamylcholine, catecholamines, 5-HT, tachykinins (SP, NKA and NKB) and opiate peptides (DYN, L-Enk and M-Enk) affect the mechanical activity of LM and CM strips isolated from the carp intestinal bulb through their specific receptors.
Regulation (affect) of NKA in intestinal bulb associated with catecholamine, opiate and substance p
20) Confidence 0.03 Published 1990 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 1981339 Disease Relevance 0 Pain Relevance 1.05

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