INT144213

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.80
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa, Calca) nucleus (Nppa, Calca) cytoplasm (Nppa, Calca)
extracellular space (Calca) aging (Calca) intracellular (Calca)
Anatomy Link Frequency
sensory neurons 4
dorsal root ganglion 2
Nppa (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 18 100.00 Very High Very High Very High
Root ganglion neuron 3 98.56 Very High Very High Very High
Spinal cord 18 97.64 Very High Very High Very High
ischemia 9 92.00 High High
antagonist 3 46.96 Quite Low
qutenza 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 98.36 Very High Very High Very High
Frailty 18 97.92 Very High Very High Very High
Spinal Cord Ischemia 3 92.96 High High
Injury 3 91.60 High High
Cv Unclassified Under Development 6 90.00 High High
Natriuresis 6 88.72 High High
Cancer 3 58.00 Quite High
Necrosis 3 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in CGRP release induced by ANP was reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation, or with (9S, 10S, 12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]-benzodiazocine-10-carboxylic acid hexyl ester (KT5720), an inhibitor of protein kinase A (PKA), suggesting that ANP might increase CGRP release from sensory neurons by activating PKA through an increase in the cellular cAMP level.
ANP Spec (might) Positive_regulation (increase) of Localization (release) of CGRP in sensory neurons associated with calcitonin gene-related peptide
1) Confidence 0.71 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17522345 Disease Relevance 1.00 Pain Relevance 0.61
ANP increased CGRP release and cellular cAMP levels in dorsal root ganglion neurons isolated from rats in vitro.
ANP Positive_regulation (increased) of Localization (release) of CGRP in dorsal root ganglion associated with ganglion cysts, root ganglion neuron and calcitonin gene-related peptide
2) Confidence 0.71 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17522345 Disease Relevance 0.91 Pain Relevance 0.52
The increase in CGRP release induced by ANP was reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation, or with (9S, 10S, 12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]-benzodiazocine-10-carboxylic acid hexyl ester (KT5720), an inhibitor of protein kinase A (PKA), suggesting that ANP might increase CGRP release from sensory neurons by activating PKA through an increase in the cellular cAMP level.
ANP Positive_regulation (induced) of Localization (release) of CGRP in sensory neurons associated with calcitonin gene-related peptide
3) Confidence 0.51 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17522345 Disease Relevance 0.89 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox