INT144231

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 12.93
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
lymph nodes 1
macrophages 1
monocytes 1
Il12b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 417 100.00 Very High Very High Very High
chemokine 106 100.00 Very High Very High Very High
Inflammatory mediators 8 99.96 Very High Very High Very High
Inflammatory response 33 99.04 Very High Very High Very High
Inflammation 272 97.92 Very High Very High Very High
psoriasis 20 95.32 Very High Very High Very High
agonist 13 93.44 High High
Multiple sclerosis 166 86.64 High High
aspirin 2 81.60 Quite High
cINOD 3 81.00 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 1835 99.82 Very High Very High Very High
INFLAMMATION 321 99.76 Very High Very High Very High
Nervous System Cancer 5 99.36 Very High Very High Very High
Cancer 1218 98.72 Very High Very High Very High
Disease 377 98.32 Very High Very High Very High
Neuroblastoma 10 97.76 Very High Very High Very High
Immunization 19 97.64 Very High Very High Very High
Mycobacterial Infection 290 97.16 Very High Very High Very High
Multiple Sclerosis 313 96.24 Very High Very High Very High
Recurrence 54 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the third trimester pregnancy, ex vivo monocytic IL12 production was also found to be about threefold lower and TNF?
Gene_expression (production) of IL12
1) Confidence 0.75 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.20 Pain Relevance 0.15
In many situations, DCs are the main source of the type I interferon and IL-12 that is necessary for NK-cells activation, and in turn IFN-?
Gene_expression (source) of IL-12
2) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.74 Pain Relevance 0.18
At this regard the use of HSV vectors expressing IL-12 or GM-CSF, two indispensable cytokines for activating DCs and boosting the strong immune responses against cancer, seems promising [197, 198].
Gene_expression (expressing) of IL-12 associated with cold sores, cancer and cytokine
3) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.92 Pain Relevance 0.13
Other vectors expressing IL-12, have been tested in different tumour models [192-195] showing efficacy in both treating the tumour and preventing recurrences after tumour-resection [199].
Gene_expression (expressing) of IL-12 associated with cancer and recurrence
4) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.22 Pain Relevance 0.03
In this regard, the gene transfer of GM-CSF into dying tumour cell may be more suitable form to elicit local antitumor responses by differentiating DC in situ and providing immunogenic tumour antigens for cross-presentation by paracrine fashion, whereas the expression of IL-12 may be an appropriate strategy to maximally boost antitumor effector functions.
Gene_expression (expression) of IL-12 associated with cancer
5) Confidence 0.75 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.78 Pain Relevance 0.07
, IL-6, IL-10, and IL-12p70 concentrations were detected by ELISA kit (R&D, USA).


Gene_expression (detected) of IL-12
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.09 Pain Relevance 0.05
Cytokines (IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, IFN-?
Gene_expression (Cytokines) of IL-12 associated with cytokine
7) Confidence 0.65 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2953483 Disease Relevance 0 Pain Relevance 0.19
B activation, decreases IL-12p70 and IL-10 production, and modulates monocytes-derived DC polarization [128].
Gene_expression (production) of IL-12 in monocytes
8) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.93 Pain Relevance 0.39
, IL-2, IL-3, IL-4, IL-6, IL-10, IL-12p70, IL-17, GM-CSF, KC, and RANTES induction discriminate between the effects of BCG relative to the inflammatory responses obtained with LPS and TNF-?
Gene_expression (effects) of IL-12 associated with chemokine and inflammatory response
9) Confidence 0.65 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.37 Pain Relevance 0.73
allows the generation of fully mature DC, with high migratory responsiveness to lymphoid organ chemokines and an ability to produce significant levels of IL12p70 after CD40 ligation (which mimics the interaction between DC and CD40L-activated cells in lymph nodes) [104].
Gene_expression (produce) of IL12 in lymph nodes associated with chemokine
10) Confidence 0.65 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 0.43 Pain Relevance 0.14
The cytokine IL-12, made up of IL-12p35 and IL-12p40 subunits is crucial for the induction of IFN?
Gene_expression (made) of IL-12 associated with cytokine
11) Confidence 0.65 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.53 Pain Relevance 0.05
The cytokine IL-12, made up of IL-12p35 and IL-12p40 subunits is crucial for the induction of IFN?
Gene_expression (made) of IL-12 associated with cytokine
12) Confidence 0.65 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.53 Pain Relevance 0.05
To our knowledge the only molecules known to regulate FAAH activity are the TH1 cytokines IL-12 and IFN?
Gene_expression (cytokines) of IL-12 associated with cytokine
13) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.62 Pain Relevance 0.13
M002 vector, derived from a replication-competent ICP34,5- mutant which expresses mIL-12 was evaluated for its antitumor activity in a syngenic neuroblastoma murine model [189].
Gene_expression (expresses) of IL-12 associated with neuroblastoma
14) Confidence 0.58 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.95 Pain Relevance 0.03
Interestingly, expression of GM-CSF and IL-23p19, but not IL-12p35, is required for the manifestation of disease in this model (8, 9, 19).
Gene_expression (expression) of IL-12 associated with disease
15) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 1.14 Pain Relevance 0.27
This decreased generation of reactive nitrogen species was mediated by PB progressively down-regulating transcription of inducible nitric oxide synthase in macrophages, and concomitantly causing a dose-dependent decrease in the expression of interleukin-12 p40, indicating the ability of PB to down-regulate T-helper 1 pro-inflammatory responses.
Gene_expression (expression) of interleukin-12 p40 in macrophages associated with inflammatory response
16) Confidence 0.24 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17524237 Disease Relevance 0.47 Pain Relevance 0.31
In particular, IL12 was the predominant cytokine expressed in patients (IL12p35 RQ=30.2 and IL12p40 RQ=29.0).
Gene_expression (expressed) of IL12
17) Confidence 0.14 Published 2008 Journal Arch. Oral Biol. Section Body Doc Link 18508030 Disease Relevance 0.14 Pain Relevance 0
In light of existing knowledge on interconnected pathways of pro-inflammatory mediators (leukotrienes, chemokines (IL8, SDF-1 alpha, MIP-1 alpha, MCP-1,2 etc), and cytokines (IL3, IL6, IL12, IL-1 beta, GM-CSF, B94, TNF-alpha etc)), the anti-inflammatory properties of pro-resolving mediators in preventing chronic inflammation which leads to carcinogenesis needs further understanding.
Gene_expression (leukotrienes) of IL12 associated with chemokine, inflammatory mediators, inflammation and cytokine
18) Confidence 0.07 Published 2009 Journal Curr. Mol. Med. Section Abstract Doc Link 19601807 Disease Relevance 0.86 Pain Relevance 0.75

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