INT144232

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.26
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
macrophages 2
monocytes 2
Il12b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 51 100.00 Very High Very High Very High
Inflammatory response 2 97.48 Very High Very High Very High
psoriasis 20 95.72 Very High Very High Very High
agonist 7 93.44 High High
Inflammation 77 91.04 High High
Multiple sclerosis 121 90.08 High High
dexamethasone 2 77.76 Quite High
Arthritis 7 76.68 Quite High
corticosteroid 2 72.80 Quite High
Endocannabinoid 18 71.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 81 97.48 Very High Very High Very High
Psoriasis 28 95.72 Very High Very High Very High
Multiple Sclerosis 221 90.08 High High
Cancer 88 82.56 Quite High
Prostate Cancer 51 80.00 Quite High
Dermatitis 28 78.04 Quite High
Skin Diseases 6 77.12 Quite High
Arthritis 1 76.68 Quite High
Pain 3 65.28 Quite High
Apoptosis 15 62.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge the only molecules known to regulate FAAH activity are the TH1 cytokines IL-12 and IFN?
Negative_regulation (knowledge) of Gene_expression (cytokines) of IL-12 associated with cytokine
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.64 Pain Relevance 0.13
B activation, decreases IL-12p70 and IL-10 production, and modulates monocytes-derived DC polarization [128].
Negative_regulation (decreases) of Gene_expression (production) of IL-12 in monocytes
2) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.94 Pain Relevance 0.40
During the third trimester pregnancy, ex vivo monocytic IL12 production was also found to be about threefold lower and TNF?
Negative_regulation (lower) of Gene_expression (production) of IL12
3) Confidence 0.41 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.21 Pain Relevance 0.18
This decreased generation of reactive nitrogen species was mediated by PB progressively down-regulating transcription of inducible nitric oxide synthase in macrophages, and concomitantly causing a dose-dependent decrease in the expression of interleukin-12 p40, indicating the ability of PB to down-regulate T-helper 1 pro-inflammatory responses.
Negative_regulation (decrease) of Gene_expression (expression) of interleukin-12 p40 in macrophages associated with inflammatory response
4) Confidence 0.18 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17524237 Disease Relevance 0.48 Pain Relevance 0.31

General Comments

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