INT144256

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1)
small molecule metabolic process (CGA) cytoplasm (NFKB1) cell-cell signaling (CGA)
Anatomy Link Frequency
stromal cells 4
CGA (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 100.00 Very High Very High Very High
Inflammatory mediators 2 99.00 Very High Very High Very High
endometriosis 2 97.62 Very High Very High Very High
Pain 2 91.84 High High
Inflammation 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 2 99.24 Very High Very High Very High
INFLAMMATION 4 98.80 Very High Very High Very High
Endometriosis 10 97.62 Very High Very High Very High
Sleep Initiation And Maintenance Disorders 2 92.56 High High
Pain 2 91.84 High High
Disease 2 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since endometriosis is associated with aberrant concentrations of inflammatory mediators in the peritoneal fluid, we investigated whether hCG may affect cytokine-dependent activation of the key-regulatory transcription factor NF-kappaB and expression of two nuclear factor kappa B (NF-kappaB)-inducible genes, tumour necrosing factor (TNF-alpha) and interleukin (IL)-1beta, in stromal cells isolated from ectopic endometriotic tissues.
hCG Regulation (affect) of Gene_expression (expression) of NF-kappaB in stromal cells associated with endometriosis, inflammatory mediators, cancer and cytokine
1) Confidence 0.21 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.83 Pain Relevance 0.31
Since endometriosis is associated with aberrant concentrations of inflammatory mediators in the peritoneal fluid, we investigated whether hCG may affect cytokine-dependent activation of the key-regulatory transcription factor NF-kappaB and expression of two nuclear factor kappa B (NF-kappaB)-inducible genes, tumour necrosing factor (TNF-alpha) and interleukin (IL)-1beta, in stromal cells isolated from ectopic endometriotic tissues.
hCG Regulation (affect) of Gene_expression (expression) of nuclear factor kappa B in stromal cells associated with endometriosis, inflammatory mediators, cancer and cytokine
2) Confidence 0.15 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.83 Pain Relevance 0.31

General Comments

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