INT144263

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.14
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (KCNK1) plasma membrane (KCNK1) cytoplasm (KCNK1)
Anatomy Link Frequency
myometrium 1
KCNK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 29 100.00 Very High Very High Very High
tetrodotoxin 1 96.20 Very High Very High Very High
imagery 2 42.28 Quite Low
Bioavailability 32 35.68 Quite Low
agonist 1 29.12 Quite Low
antagonist 3 22.36 Low Low
corticosteroid 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
transdermal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-term Labor 5 72.12 Quite High
Premature Birth 3 19.52 Low Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Blister 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 5 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Fungal Infection 4 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 2 5.00 Very Low Very Low Very Low
Skin Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although claimed to be absent in murine myometrium [18], we have described the expression of the potassium channels, subfamily K, member 4 (KCNK4) a two-pore potassium channel (K2P4.1) known as TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) and member 2 (KCNK2) a two-pore potassium channel (K2P2.1) known as TREK-1 (TWIK-related K+ channel) in human myometrium [19] as did Bai et al. in the same year [20].
Gene_expression (expression) of K2P in myometrium associated with potassium channel
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.14 Pain Relevance 0.34
In the RT-PCR analysis, Kv1.1, Kv4.2, Kv1.4, Kir2.1, heag1, MaxiK, hNE-Na, and TWIK-1 were detected.
Gene_expression (detected) of TWIK-1
2) Confidence 0.43 Published 2007 Journal Stem Cells Section Abstract Doc Link 17525238 Disease Relevance 0 Pain Relevance 0.10
These physicochemical parameters are relevant to DPK in that they report, respectively, on the extent and the rate of drug uptake into the SC: the partition coefficient (K) reflects the relative affinity of the drug for the SC compared to the applied formulation and is related to the extent of absorption, therefore; the ratio D/L2 has units of (time)?
Gene_expression (relevant) of DPK
3) Confidence 0.34 Published 2007 Journal Pharm Res Section Body Doc Link PMC2217624 Disease Relevance 0 Pain Relevance 0

General Comments

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