INT144264

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 6
Total Number 28
Disease Relevance 17.69
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (KCNH1)
Anatomy Link Frequency
surface epithelium 1
SH-SY5Y 1
EFM-19 1
MCF-7 1
bone marrow 1
KCNH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 127 100.00 Very High Very High Very High
tetrodotoxin 37 100.00 Very High Very High Very High
Central nervous system 23 100.00 Very High Very High Very High
sodium channel 12 100.00 Very High Very High Very High
anesthesia 26 99.76 Very High Very High Very High
Calcium channel 9 99.60 Very High Very High Very High
Action potential 26 82.00 Quite High
alcohol 46 61.44 Quite High
addiction 3 58.04 Quite High
Rsd 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 667 99.92 Very High Very High Very High
Ovarian Cancer 713 99.84 Very High Very High Very High
Sarcoma 23 98.60 Very High Very High Very High
Disease 279 98.36 Very High Very High Very High
Cervical Cancer 23 97.40 Very High Very High Very High
Neuroblastoma 46 97.00 Very High Very High Very High
Carcinoma 23 96.40 Very High Very High Very High
Glioma 23 90.96 High High
Toxicity 23 86.44 High High
Cardiovascular Disorder Under Development 23 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modified nucleotides are shown in lower case and introduced ClaI and EagI sites are underlined.
Gene_expression (introduced) of EagI
1) Confidence 0.65 Published 2008 Journal Journal of Experimental Botany Section Body Doc Link PMC2486475 Disease Relevance 0.07 Pain Relevance 0
We show here that high Eag expression is associated with poor prognosis in patients with ovarian cancer.
Gene_expression (expression) of Eag associated with ovarian cancer
2) Confidence 0.64 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.10 Pain Relevance 0
Four main K+ channel subtypes (Kv1.3, K2p9.1, Eag and HERG) are found to be overexpressed in a number of tumour types [4].
Gene_expression (overexpressed) of Eag associated with cancer
3) Confidence 0.64 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.72 Pain Relevance 0
High Eag expression is also associated with high grade ovarian cancers and the presence of residual disease at surgery, which in turn is associated with poor outcome, but no correlation between tumour stage, histological type or adjuvant chemotherapy was demonstrated.
Gene_expression (expression) of Eag associated with cancer, ovarian cancer and disease
4) Confidence 0.64 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.16 Pain Relevance 0
Eag expression has also been detected by RT-PCR in cell lines from different organs including as He-La (carcinoma of cervix), SH_SY5Y (neuroblastoma) and various mammary cell lines (COLO-824, EFM-19, BT_474).
Gene_expression (expression) of Eag in EFM-19 associated with neuroblastoma and carcinoma
5) Confidence 0.64 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.60 Pain Relevance 0.13
This is the first study to examine the expression of Eag and HERG channels in ovarian cancer biopsies, with subsequent relation to prognostic factors.
Spec (examine) Gene_expression (expression) of Eag associated with ovarian cancer
6) Confidence 0.64 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.20 Pain Relevance 0.03
Inhibition of Eag expression in EFM-19, HeLA, MCF-7, and SH-SY5Y cell lines with antisense oligonucleotides reduced their growth, demonstrating a role for Eag in cell proliferation [12].
Gene_expression (expression) of Eag in SH-SY5Y
7) Confidence 0.64 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.68 Pain Relevance 0.15
Staining of normal ovary (n = 6) demonstrated low level expression of both Eag and HERG on the surface epithelium compared to ovarian cancer (shown by arrow in Figure 3C).


Gene_expression (expression) of Eag in surface epithelium associated with ovarian cancer
8) Confidence 0.64 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.77 Pain Relevance 0
In the RT-PCR analysis, Kv1.1, Kv4.2, Kv1.4, Kir2.1, heag1, MaxiK, hNE-Na, and TWIK-1 were detected.
Gene_expression (detected) of heag1
9) Confidence 0.58 Published 2007 Journal Stem Cells Section Abstract Doc Link 17525238 Disease Relevance 0 Pain Relevance 0.10
Eag channel expression has also been demonstrated in various clinical tumours [10] and cervical cancer [13].
Gene_expression (expression) of Eag associated with cervical cancer and cancer
10) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.84 Pain Relevance 0.14
Diffuse staining of the cytoplasm and nuclei was seen with both Eag (Figure 2A) and HERG antibody (Figure 2B).
Gene_expression (antibody) of Eag
11) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.13 Pain Relevance 0.04
Eag has a restricted distribution limited to the central nervous system [10] and expressed transiently in myoblasts [11].
Gene_expression (expressed) of Eag in myoblasts associated with central nervous system
12) Confidence 0.55 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.66 Pain Relevance 0.15
Both K+ channel blockers, 4-AP and TEA, significantly inhibited the proliferation of Eag and HERG-positive SK-OV-3 cells, confirming data by Zhanping et al., on the A2780 ovarian cancer line [5].
Gene_expression (positive) of Eag in A2780 associated with ovarian cancer
13) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.79 Pain Relevance 0
We show for the first time that high expression of Eag channels in ovarian cancer patients is significantly associated with poor survival (P = 0.016) unlike HERG channel expression where there was no correlation with survival.
Gene_expression (expression) of Eag associated with ovarian cancer
14) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC3016344 Disease Relevance 0.95 Pain Relevance 0.17
The expression of Eag and HERG potassium channels was examined in an ovarian cancer tissue microarray.
Spec (examined) Gene_expression (expression) of Eag associated with ovarian cancer and potassium channel
15) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC3016344 Disease Relevance 0.95 Pain Relevance 0.18
In summary, we have demonstrated for the first time that Eag and HERG K+ channels are overexpressed in ovarian cancer and that high Eag staining is associated with significantly poorer survival, identifying Eag as a putative prognostic marker.
Gene_expression (overexpressed) of Eag associated with ovarian cancer
16) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.56 Pain Relevance 0
Eag and HERG potassium channels are expressed in the SK-OV-3 cell line
Gene_expression (expressed) of Eag in SK-OV-3 associated with potassium channel
17) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.16 Pain Relevance 0.08
Implantation of Eag-transfected cells in severe combined immune deficient mice resulted in tumour formation.
Gene_expression (transfected) of Eag associated with cancer
18) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 0.62 Pain Relevance 0.13
In contrast to our findings, no association has been shown between Eag expression and different grades of tumour in soft tissue sarcoma patients [23] which may be due to the non epithelial origin of these tumours.
Gene_expression (expression) of Eag associated with sarcoma and cancer
19) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.13 Pain Relevance 0
Eag channels are expressed on the surface of the cell membrane are attractive targets for novel treatments in management of ovarian cancer.
Gene_expression (expressed) of Eag associated with ovarian cancer
20) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3016344 Disease Relevance 1.06 Pain Relevance 0

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