INT144274

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 3.21
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cav3) Golgi apparatus (Cav3) plasma membrane organization (Cav3)
plasma membrane (Cav3) enzyme binding (Cav3) protein complex (Cav3)
Anatomy Link Frequency
chondrocytes 6
neurons 5
muscle 2
cardiac myocytes 1
spikes 1
Cav3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 14 99.78 Very High Very High Very High
Inflammation 75 97.60 Very High Very High Very High
Hyperalgesia 5 95.36 Very High Very High Very High
Action potential 93 94.92 High High
COX-2 inhibitor 15 93.92 High High
Spinal cord 2 93.40 High High
Pain 15 90.48 High High
Arthritis 15 89.84 High High
potassium channel 3 82.64 Quite High
Calcium channel 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 14 99.78 Very High Very High Very High
Nociception 4 98.40 Very High Very High Very High
INFLAMMATION 45 97.60 Very High Very High Very High
Hypertrophy 6 97.24 Very High Very High Very High
Hyperalgesia 6 95.36 Very High Very High Very High
Shock 3 90.84 High High
Pain 15 90.48 High High
Arthritis 45 89.84 High High
Aging 33 76.44 Quite High
Obesity 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of caveolin-3 in the fibroblast-like type B synoviocytes in the rat temporomandibular joint.
Gene_expression (Expression) of caveolin-3 in fibroblast associated with snapping jaw
1) Confidence 0.78 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 17525939 Disease Relevance 0.19 Pain Relevance 0.19
Results suggest that Cav3 expression, which is closely related to added functional stimuli, reflects the differentiation of the type B synoviocytes.
Gene_expression (expression) of Cav3
2) Confidence 0.77 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18286598 Disease Relevance 0.36 Pain Relevance 0.26
However, the involvement of Cav3 expression in the differentiation and maturation of type B cells remains unclear.
Gene_expression (expression) of Cav3 in B cells
3) Confidence 0.77 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18286598 Disease Relevance 0.35 Pain Relevance 0.35
Our recent study on the temporomandibular joint (TMJ) revealed expressions of Cav1 and muscle-specific Cav3 in some synovial fibroblast-like type B cells with well-developed caveolae.
Gene_expression (expressions) of Cav3 in muscle associated with snapping jaw
4) Confidence 0.77 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18286598 Disease Relevance 0.35 Pain Relevance 0.35
The results shown in Fig. 2 indicate that the expressions of Cav-3 mRNA and protein were observed in the un-stimulated rat chondrocytes.
Gene_expression (expressions) of Cav-3 mRNA in chondrocytes
5) Confidence 0.68 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
In 1999, Schwab and co-workers (12) reported that rat chondrocytes cultured from the femoral and tibial articular surfaces of knee joints of newborn rat also expressed Cav-3.
Gene_expression (expressed) of Cav-3 in chondrocytes
6) Confidence 0.68 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0.28 Pain Relevance 0.23
With respect to the tissue distribution of Cav-3, there have been two current investigations that have demonstrated the expression of Cav-3 in other tissues.
Gene_expression (expression) of Cav-3
7) Confidence 0.68 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
The expressions of Cav-3 mRNA and protein were decreased by the treatment with Cd.


Gene_expression (expressions) of Cav-3 mRNA
8) Confidence 0.68 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Cav-3 was shown to be specifically expressed in muscle and it was also detected in brain astroglial cells (11).
Gene_expression (expressed) of Cav-3 in muscle
9) Confidence 0.68 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0.22 Pain Relevance 0.18
We examined the expressions of COX-2 and Cav-3 mRNAs and proteins in the normal or Cd-treated rat chondrocytes.
Spec (examined) Gene_expression (expressions) of Cav-3 in chondrocytes
10) Confidence 0.68 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
With respect to the tissue distribution of Cav-3, there have been two current investigations that have demonstrated the expression of Cav-3 in other tissues.
Gene_expression (expression) of Cav-3
11) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
The COX-2 or Cav-3 proteins did not precipitate with the control IgG (Fig. 4A, B, designated none).
Gene_expression (proteins) of Cav-3
12) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Co-precipitation of COX-2 with Cav-3 in the Cd-treated rat chondrocytes
Gene_expression (precipitation) of Cav-3 in chondrocytes
13) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Glutathione S-Transferase (GST)-COX-2 and -Caveolin-3 fusion protein
Gene_expression (protein) of Caveolin-3
14) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
These membrane fractions also contained Cav-3 protein (Fig. 3).


Gene_expression (contained) of Cav-3 protein
15) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
An unexpected interesting result from the current study was the expressional change of Cav-3.
Gene_expression (expressional) of Cav-3
16) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
The caveolin family consists of Cav-1, Cav-2 and Cav-3 (26, 27).
Gene_expression (consists) of Cav-3
17) Confidence 0.59 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Our findings thus establish that spinal and peripheral NaHS/H2S activates or sensitizes Cav3.2 T-type Ca2+ channels expressed in the primary afferents and/or spinal nociceptive neurons, leading to sensitization of nociceptive processing and hyperalgesia.
Gene_expression (expressed) of Cav3 in neurons associated with nociception and hyperalgesia
18) Confidence 0.58 Published 2009 Journal Pain Section Abstract Doc Link 19167819 Disease Relevance 0.79 Pain Relevance 0.51
Expression of COX-2 and Caveolin-3 in the normal or Cd-treated rat chondrocytes
Gene_expression (Expression) of Caveolin-3 in chondrocytes
19) Confidence 0.52 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Upon treating the chondrocytes with 5 ┬ÁM of CdCl2 (Cd) for 6 hr, the expressions of COX-2 mRNA and protein were increased with the decreased Cav-3 mRNA and protein expressions.
Gene_expression (expressions) of Cav-3 mRNA in chondrocytes
20) Confidence 0.52 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0

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