INT144275

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 8.48
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm) cell cycle (Atm) DNA binding (Atm)
kinase activity (Atm) cytoplasm (Atm)
Anatomy Link Frequency
neck 1
neuronal 1
Leukocyte 1
bone marrow 1
head 1
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 9 93.80 High High
cytokine 8 81.84 Quite High
palliative 8 65.08 Quite High
Pain 6 14.76 Low Low
fibrosis 14 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 56 98.08 Very High Very High Very High
Squamous Cell Carcinoma 20 97.88 Very High Very High Very High
Disease 26 97.28 Very High Very High Very High
Telangiectasia 48 95.84 Very High Very High Very High
Dna Damage 1 95.28 Very High Very High Very High
Breast Cancer 118 92.72 High High
Female Infertility 1 92.40 High High
Recurrence 42 92.12 High High
Apoptosis 145 91.76 High High
Ataxia 30 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in p53 mutated cell lines, disruption of ATM resulted in defective G2/M checkpoint control, radio-resistant DNA synthesis, retarded cell proliferation and enhanced radiosensitivity[15,16].
Negative_regulation (disruption) of ATM
1) Confidence 0.59 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.60 Pain Relevance 0
Rasheed had found that disruption of the ATM gene in mice resulted in exquisite sensitivity to low doses of ionizing radiation[24].
Negative_regulation (disruption) of ATM
2) Confidence 0.43 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.73 Pain Relevance 0
Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice

Background

Negative_regulation (inhibition) of ATM in neck associated with squamous cell carcinoma
3) Confidence 0.43 Published 2008 Journal J Exp Clin Cancer Res Section Title Doc Link PMC2584003 Disease Relevance 0.38 Pain Relevance 0
Functional inactivation of the ATM gene product and Atm-null mice, which were created by disrupting the Atm locus, recapitulate the human A-T phenotype and display growth retardation, mild neurological dysfunction, male and female infertility, extreme predisposition to thymic lymphomas, and acute sensitivity to ionizing radiation [1-3].
Negative_regulation (inactivation) of ATM associated with anesthesia, lymphatic system cancer, telangiectasia and female infertility
4) Confidence 0.43 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.83 Pain Relevance 0.09
Leukocyte DNA was available for all 104 samples but mutation screening of the ATM gene was only performed for 44 of the patients experiencing IBCT and 51 of the matched controls.
Negative_regulation (screening) of ATM in Leukocyte
5) Confidence 0.39 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.87 Pain Relevance 0
Three high risk groups of truncating mutations were identified each of which were associated to a known binding domain of the ATM protein.
Negative_regulation (domain) of ATM
6) Confidence 0.39 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.75 Pain Relevance 0
It was also found that cell percentage of G2/M phase was decreased dramatically in ATM AS-ODNs transfected cells at 48 hours after 2 Gy irradiation compared with that of other groups(P < 0.05; Figure. 5).


Negative_regulation (decreased) of ATM
7) Confidence 0.37 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2584003 Disease Relevance 0.39 Pain Relevance 0
The potential connection between this phenotype and other clinical symptoms caused by ATM deficiency, such as progressive neuronal degeneration, is discussed in this article.
Negative_regulation (deficiency) of ATM in neuronal
8) Confidence 0.37 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17525940 Disease Relevance 0.57 Pain Relevance 0.07
MCL patients bearing ATM inactivation seem not to have a worse prognosis, while recent in vitro data suggest that ATM loss may actually contribute to radiosensitivity of MCL cells [26].
Negative_regulation (loss) of ATM associated with mantle-cell lymphoma
9) Confidence 0.28 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1569379 Disease Relevance 0.94 Pain Relevance 0
While the ATM gene is thought to play a key-role in detecting radiation-induced DNA damage (expecially Double Strand Breaks), recent in vitro data support the hypothesis that ATM loss may actually contribute to the radiosensitivity of MCL cells.
Negative_regulation (loss) of ATM associated with mantle-cell lymphoma
10) Confidence 0.28 Published 2006 Journal Radiat Oncol Section Abstract Doc Link PMC1569379 Disease Relevance 0.73 Pain Relevance 0.11
ATM status was retrospectively investigated in our patient, with the tool of Fluorescence In Situ Hybridization, showing a complete inactivation of a single ATM allele secondary to the deletion of chromosomal region 11q22-23.
Negative_regulation (inactivation) of ATM
11) Confidence 0.21 Published 2006 Journal Radiat Oncol Section Abstract Doc Link PMC1569379 Disease Relevance 0.53 Pain Relevance 0.09
ATM status was retrospectively investigated in our patient, with the tool of Fluorescence In Situ Hybridization (FISH) on bone marrow biopsy at diagnosis, showing a complete inactivation of a single ATM allele secondary to a deletion of chromosomal region 11q22-23.
Negative_regulation (inactivation) of ATM in bone marrow
12) Confidence 0.21 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1569379 Disease Relevance 0.77 Pain Relevance 0
Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice

Background

Negative_regulation (inhibition) of ATM in head associated with squamous cell carcinoma
13) Confidence 0.15 Published 2008 Journal J Exp Clin Cancer Res Section Title Doc Link PMC2584003 Disease Relevance 0.38 Pain Relevance 0

General Comments

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