INT144289

Context Info Confidence 0.41 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0.92

cytosol (PSMC6) nucleoplasm (PSMC6) small molecule metabolic process (PSMC6) ATPase activity (PSMC6) nucleus (PSMC6) protein binding, bridging (PSMC6)

PSMC6 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 12 99.40

Disease Link Frequency Relevance Heat Apoptosis 2 96.52 Toxicity 1 96.04 Hepatocellular Cancer 4 68.48 Cancer 2 57.80 Death 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, suppression of p44/42 activation by the p44/42-MAPK inhibitor 2'-amino-3'-methoxyflavone (PD98059) blocked DOX-induced apoptosis.

Negative_regulation (suppression) of Positive_regulation (activation) of p44 associated with apoptosis

1) Confidence 0.41 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17526808 Disease Relevance 0.56 Pain Relevance 0.92

General Comments

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