INT144314

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 12.29
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (INHBA) growth (INHBA) extracellular region (INHBA)
cell-cell signaling (INHBA)
Anatomy Link Frequency
amniotic fluid 10
margin 2
internal 2
placenta 2
skin 1
INHBA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 17 54.36 Quite High
Inflammation 12 50.00 Quite Low
epidural 1 50.00 Quite Low
analgesia 1 50.00 Quite Low
Osteoarthritis 5 48.08 Quite Low
fibrosis 15 39.12 Quite Low
abdominal pain 12 38.56 Quite Low
headache 14 36.84 Quite Low
positron emission tomography 2 22.00 Low Low
imagery 2 16.96 Low Low
Disease Link Frequency Relevance Heat
Dermal Scarring 240 100.00 Very High Very High Very High
Repression 2 99.44 Very High Very High Very High
Nasopharynx Cancer 290 98.80 Very High Very High Very High
Pre-eclampsia 504 98.76 Very High Very High Very High
Disease 159 96.68 Very High Very High Very High
Cancer 108 94.28 High High
Keloid Scars 30 91.44 High High
Carcinoma 4 91.20 High High
Syndrome 12 81.08 Quite High
Injury 15 64.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During pregnancy, the placenta produces and secretes inhibin A, which then enters both the maternal and the fetal circulation (11,12,23).
Gene_expression (produces) of inhibin in placenta
1) Confidence 0.73 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.60 Pain Relevance 0
Intrapartum temperature elevation was not associated with histologic signs of placental inflammation or with expression of activin betaA in the placenta.
Gene_expression (expression) of activin in placenta
2) Confidence 0.65 Published 2007 Journal J Clin Anesth Section Body Doc Link 17531723 Disease Relevance 0 Pain Relevance 0
Our results also indicated the amniotic fluid inhibin A levels were significantly higher in patients who subsequently developed severe preeclampsia than those in normal pregnant women.
Gene_expression (levels) of inhibin in amniotic fluid associated with pre-eclampsia
3) Confidence 0.64 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.62 Pain Relevance 0
The placental inhibin A that enters maternal and the fetal circulation may cause an elevation in maternal serum and amniotic fluid inhibin A levels.
Gene_expression (levels) of inhibin in amniotic fluid
4) Confidence 0.64 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.64 Pain Relevance 0
In addition, we compared the correlation between maternal serum and amniotic fluid inhibin A levels in both normal pregnant women and subsequently severe preeclampsia.


Gene_expression (levels) of inhibin in amniotic fluid associated with pre-eclampsia
5) Confidence 0.64 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.72 Pain Relevance 0
Moreover, inhibin A levels in amniotic fluid were significantly higher than those in maternal serum for this disease.
Gene_expression (levels) of inhibin in amniotic fluid associated with disease
6) Confidence 0.64 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.63 Pain Relevance 0
There is a positive correlation between elevated maternal serum and amniotic fluid inhibin A levels in patients who subsequently developed severe preeclampsia.
Gene_expression (levels) of inhibin in amniotic fluid associated with pre-eclampsia
7) Confidence 0.64 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.56 Pain Relevance 0
We observed that the amniotic fluid inhibin A levels were positively correlated with the maternal serum inhibin A levels in the patients who subsequently developed severe preeclampsia.
Gene_expression (levels) of inhibin in amniotic fluid associated with pre-eclampsia
8) Confidence 0.57 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.65 Pain Relevance 0
As inhibin A levels in this study were not normally distributed, a Mann-Whitney U tests were used for comparison of continuous variables, and proportions were compared with the ?
Gene_expression (levels) of inhibin
9) Confidence 0.57 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.07 Pain Relevance 0
This is the first report for inhibin A levels in the second trimester amniotic fluid of the patients who subsequently developed severe preeclampsia.
Gene_expression (levels) of inhibin in amniotic fluid associated with pre-eclampsia
10) Confidence 0.57 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.65 Pain Relevance 0
In contrast, there was no correlation between amniotic fluid and maternal serum inhibin A levels in the control group (r=0.185, p=0.126).
Gene_expression (levels) of inhibin in amniotic fluid
11) Confidence 0.57 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.50 Pain Relevance 0
We observed that the amniotic fluid inhibin A levels were positively correlated with the maternal serum inhibin A levels in the patients who subsequently developed severe preeclampsia.
Gene_expression (levels) of inhibin in amniotic fluid associated with pre-eclampsia
12) Confidence 0.55 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.70 Pain Relevance 0
However, a downregulation of INHBA protein level was observed when comparing keloid margin with external normal skin.7 In addition, Seifert et al7 also noted an increased expression of inhibitor for INHBA at the margin.
Gene_expression (expression) of INHBA in skin associated with dermal scarring
13) Confidence 0.53 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.89 Pain Relevance 0.08
Our data suggest that amniotic fluid may be another significant source of inhibin A for the prediction of severe preeclampsia.
Gene_expression (source) of inhibin in amniotic fluid associated with pre-eclampsia
14) Confidence 0.50 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729950 Disease Relevance 0.60 Pain Relevance 0
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of INHBA in internal associated with dermal scarring
15) Confidence 0.47 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of INHBA in internal associated with dermal scarring
16) Confidence 0.47 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
Ten of these 19 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5), demonstrated a statistically significant difference for the gene expression levels between keloid margin and internal control skin.
Gene_expression (expression) of INHBA in margin associated with dermal scarring
17) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.66 Pain Relevance 0
A statistically significant (P < .05) differential expression and a fold change of more than 2 were determined between keloid margin and internal control biopsy samples for 10 genes, including ACAN, ASPN, C5orf13, HIF1A, IGFBP7, INHBA, LGALS1, PTN, SERPINH1, and TNFAIP6 (Table 5).
Gene_expression (expression) of INHBA in margin associated with dermal scarring
18) Confidence 0.16 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.24 Pain Relevance 0
RASSF1A-induced repression of Id2 was mediated by the overexpression of activin ?
Gene_expression (overexpression) of activin associated with repression
19) Confidence 0.02 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.35 Pain Relevance 0
Investigated by high-density oligonucleotide array, the expressions of activin ?
Gene_expression (expressions) of activin
20) Confidence 0.02 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.31 Pain Relevance 0

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