INT144322

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.90
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RPE) cytosol (RPE) small molecule metabolic process (RPE)
carbohydrate metabolic process (RPE)
Anatomy Link Frequency
RPE 1
choroid 1
RPE (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 78.24 Quite High
adenocard 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
interneuron 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 15 98.82 Very High Very High Very High
Age-related Macular Degeneration 74 95.64 Very High Very High Very High
Aging 5 84.28 Quite High
Disease 57 76.64 Quite High
Geographic Atrophy 1 45.76 Quite Low
Stress 4 37.92 Quite Low
Optic Atrophy 1 37.84 Quite Low
Glaucoma 2 37.08 Quite Low
Cataract 1 36.68 Quite Low
Adhesions 2 31.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functional peculiarity of the macular region, epigenetic phenomena leading to an age-related shift in protein expression, along with the accumulation of lipofuscin may affect the metabolism in the central RPE.
Spec (may) Regulation (affect) of RPE in RPE
1) Confidence 0.24 Published 2007 Journal Prog Retin Eye Res Section Abstract Doc Link 17532250 Disease Relevance 0.82 Pain Relevance 0.08
Complement components are found alongside drusen and the RPE-choroid interface [110], and abnormal macular dysregulation of the complement cascade in RPE and Bruch's membrane appears to cause unrestrained complement activation and drusen formation [112].
Spec (appears) Regulation (dysregulation) of RPE in choroid associated with ocular toxicity (including many sub-types)
2) Confidence 0.06 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.08 Pain Relevance 0

General Comments

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