INT144340

Context Info Confidence 0.67 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 8 Disease Relevance 1.85 Pain Relevance 1.05

plasma membrane (Qrfpr) signal transducer activity (Qrfpr)

Anatomy Link Frequency spinal cord 1 brain 1 Qrfpr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 4 99.72 midbrain 2 98.40 Central nervous system 10 98.22 medulla 4 97.28 headache 30 86.76 Analgesic 12 67.20 Neuropeptide 6 38.72 Pain 2 25.92 Dorsal horn 2 25.00 Potency 6 8.68

Disease Link Frequency Relevance Heat Malaria 618 99.82 Mycobacterial Infection 6 99.58 Acquired Immune Deficiency Syndrome Or Hiv Infection 12 99.30 Headache 30 86.76 Pneumonia 6 69.24 Fever 66 67.52 Disease 36 50.60 Lower Respiratory Tract Infection 6 45.16 Overactive Bladder 12 27.20 Pain 2 25.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS). 26RFa binding sites were widely distributed in the brain and spinal cord, whereas the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata, suggesting that 26RFa can bind to a receptor(s) other than GPR103.

Gene_expression (expression) of GPR103 in brain associated with medulla, midbrain, central nervous system and spinal cord

1) Confidence 0.67 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0 Pain Relevance 0.32

The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS). 26RFa binding sites were widely distributed in the brain and spinal cord, whereas the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata, suggesting that 26RFa can bind to a receptor(s) other than GPR103.

Gene_expression (expression) of GPR103 in spinal cord associated with medulla, midbrain, central nervous system and spinal cord

2) Confidence 0.23 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0 Pain Relevance 0.32

Availability and Use of AS-AQ and other antimalarials

Gene_expression (Availability) of AS-AQ

3) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.13 Pain Relevance 0.13

Awareness of AS-AQ among sampled households and all households in the study area

Gene_expression (Awareness) of AS-AQ

4) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0 Pain Relevance 0.07

Motivational factors to use AS-AQ

Gene_expression (use) of AS-AQ

5) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.21 Pain Relevance 0.21

Participants in the discussions who were hearing about AS-AQ for the first time were ready to learn about it and tell others.

Gene_expression (hearing) of AS-AQ

6) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.06 Pain Relevance 0

It was however observed that community member had difficulty pronouncing AS-AQ.

Gene_expression (pronouncing) of AS-AQ

7) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.19 Pain Relevance 0

Additionally existing and new funding mechanisms such as the Affordable Medicines Facility -malaria (AMFm) hosted by the Global Fund to fight AIDS, Tuberculosis and Malaria seek to make ACTs including AS-AQ affordable (about 0.05 USD) in the private and public sectors [30].

Gene_expression (make) of AS-AQ associated with mycobacterial infection, malaria and acquired immune deficiency syndrome or hiv infection

8) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 1.26 Pain Relevance 0

General Comments

This test has worked.