INT144340

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 1.85
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Qrfpr) signal transducer activity (Qrfpr)
Anatomy Link Frequency
spinal cord 1
brain 1
Qrfpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.72 Very High Very High Very High
midbrain 2 98.40 Very High Very High Very High
Central nervous system 10 98.22 Very High Very High Very High
medulla 4 97.28 Very High Very High Very High
headache 30 86.76 High High
Analgesic 12 67.20 Quite High
Neuropeptide 6 38.72 Quite Low
Pain 2 25.92 Quite Low
Dorsal horn 2 25.00 Low Low
Potency 6 8.68 Low Low
Disease Link Frequency Relevance Heat
Malaria 618 99.82 Very High Very High Very High
Mycobacterial Infection 6 99.58 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 99.30 Very High Very High Very High
Headache 30 86.76 High High
Pneumonia 6 69.24 Quite High
Fever 66 67.52 Quite High
Disease 36 50.60 Quite High
Lower Respiratory Tract Infection 6 45.16 Quite Low
Overactive Bladder 12 27.20 Quite Low
Pain 2 25.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS). 26RFa binding sites were widely distributed in the brain and spinal cord, whereas the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata, suggesting that 26RFa can bind to a receptor(s) other than GPR103.
Gene_expression (expression) of GPR103 in brain associated with medulla, midbrain, central nervous system and spinal cord
1) Confidence 0.67 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0 Pain Relevance 0.32
The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS). 26RFa binding sites were widely distributed in the brain and spinal cord, whereas the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata, suggesting that 26RFa can bind to a receptor(s) other than GPR103.
Gene_expression (expression) of GPR103 in spinal cord associated with medulla, midbrain, central nervous system and spinal cord
2) Confidence 0.23 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0 Pain Relevance 0.32
Availability and Use of AS-AQ and other antimalarials
Gene_expression (Availability) of AS-AQ
3) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.13 Pain Relevance 0.13
Awareness of AS-AQ among sampled households and all households in the study area
Gene_expression (Awareness) of AS-AQ
4) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0 Pain Relevance 0.07
Motivational factors to use AS-AQ
Gene_expression (use) of AS-AQ
5) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.21 Pain Relevance 0.21
Participants in the discussions who were hearing about AS-AQ for the first time were ready to learn about it and tell others.
Gene_expression (hearing) of AS-AQ
6) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.06 Pain Relevance 0
It was however observed that community member had difficulty pronouncing AS-AQ.
Gene_expression (pronouncing) of AS-AQ
7) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.19 Pain Relevance 0
Additionally existing and new funding mechanisms such as the Affordable Medicines Facility -malaria (AMFm) hosted by the Global Fund to fight AIDS, Tuberculosis and Malaria seek to make ACTs including AS-AQ affordable (about 0.05 USD) in the private and public sectors [30].
Gene_expression (make) of AS-AQ associated with mycobacterial infection, malaria and acquired immune deficiency syndrome or hiv infection
8) Confidence 0.07 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 1.26 Pain Relevance 0

General Comments

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