INT144341

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 0.89
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Qrfpr) signal transducer activity (Qrfpr)
Anatomy Link Frequency
spinal cord 1
brain 1
Heads 1
Qrfpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 4 99.24 Very High Very High Very High
midbrain 2 98.70 Very High Very High Very High
Spinal cord 5 97.06 Very High Very High Very High
headache 30 96.68 Very High Very High Very High
Central nervous system 10 95.56 Very High Very High Very High
Pain 4 89.60 High High
Locus ceruleus 1 85.28 High High
Raphe 1 83.04 Quite High
parabrachial 1 81.20 Quite High
Intracerebroventricular 5 76.48 Quite High
Disease Link Frequency Relevance Heat
Headache 30 96.68 Very High Very High Very High
Pain 3 89.60 High High
Fever 66 78.96 Quite High
Disease 36 76.64 Quite High
Malaria 618 75.12 Quite High
Polio 6 42.88 Quite Low
Nociception 2 25.00 Low Low
Dizziness 12 8.80 Low Low
Bites And Stings 24 5.00 Very Low Very Low Very Low
Falciparum Malaria 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS). 26RFa binding sites were widely distributed in the brain and spinal cord, whereas the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata, suggesting that 26RFa can bind to a receptor(s) other than GPR103.
GPR103 Binding (bind) of in brain associated with medulla, midbrain, central nervous system and spinal cord
1) Confidence 0.36 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0 Pain Relevance 0.35
Recently, an endogenous ligand for GPR103, 26RFa, was identified.
GPR103 Binding (ligand) of
2) Confidence 0.35 Published 2009 Journal Peptides Section Abstract Doc Link 19520126 Disease Relevance 0.09 Pain Relevance 0.46
The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS). 26RFa binding sites were widely distributed in the brain and spinal cord, whereas the expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata, suggesting that 26RFa can bind to a receptor(s) other than GPR103.
GPR103 Binding (bind) of in spinal cord associated with medulla, midbrain, central nervous system and spinal cord
3) Confidence 0.12 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0 Pain Relevance 0.35
Their information about AS-AQ was through periodic updates by the Pharmacy Council of Ghana and the district health directorates.


AS-AQ Binding (information) of
4) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.13 Pain Relevance 0.08
Community members who were aware of AS-AQ reported of diverse sources of their information about AS-AQ, the commonest being the local radio and/or the National Television stations.
AS-AQ Binding (information) of
5) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0 Pain Relevance 0
Traditional healers referred patients who complained about any side-effect after taking AS-AQ back to the government health facilities where the drug was obtained.
AS-AQ Binding (taking) of
6) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.17 Pain Relevance 0.17
An acronym for AS-AQ that is easily pronounced and recalled has to be introduced so that it can be used as a household cliché.
AS-AQ Binding (acronym) of
7) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.15 Pain Relevance 0
Heads and staff of all government health facilities including district hospitals, health centres and community clinics were aware of AS-AQ and were already prescribing the drug to their clients.
AS-AQ Binding (prescribing) of in Heads
8) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.22 Pain Relevance 0
Radio discussions, community durbars and church announcements were methods suggested to be used in disseminating information about AS-AQ.
AS-AQ Binding (information) of
9) Confidence 0.04 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2914078 Disease Relevance 0.13 Pain Relevance 0

General Comments

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