INT14436

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Context Info
Confidence 0.72
First Reported 1981
Last Reported 2008
Negated 3
Speculated 0
Reported most in Abstract
Documents 42
Total Number 42
Disease Relevance 9.90
Pain Relevance 19.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
adrenal medulla 5
nerve 3
neurons 3
area postrema 2
sweat gland 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 258 100.00 Very High Very High Very High
Enkephalin 91 100.00 Very High Very High Very High
substance P 55 100.00 Very High Very High Very High
Catecholamine 53 100.00 Very High Very High Very High
Neuropeptide 49 100.00 Very High Very High Very High
gABA 31 99.98 Very High Very High Very High
medulla 45 99.96 Very High Very High Very High
Calcitonin gene-related peptide 49 99.94 Very High Very High Very High
Catechol-O-methyltransferase 5 99.92 Very High Very High Very High
noradrenaline 7 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 305 100.00 Very High Very High Very High
Ganglion Cysts 48 99.84 Very High Very High Very High
Toxocariasis 9 99.74 Very High Very High Very High
Stress 26 99.52 Very High Very High Very High
Overdose 3 99.22 Very High Very High Very High
Syndrome 35 98.98 Very High Very High Very High
Injury 21 98.60 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.00 Very High Very High Very High
Cancer 2 96.92 Very High Very High Very High
Reprotox - General 1 2 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We can conclude that nervous stimulation of the adrenal medulla (by insulin and reserpine) induces the synthesis of enkephalins, dopamine beta-hydroxylase, the amine carrier and chromogranin B whereas the level of chromogranin A apparently depends on corticosteroids.
Gene_expression (synthesis) of dopamine beta-hydroxylase in adrenal medulla associated with medulla, corticosteroid, dopamine and enkephalin
1) Confidence 0.72 Published 1987 Journal Neuroscience Section Abstract Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.76
In rat, noradrenaline and dopamine beta-hydroxylase were mainly present in the upper fractions of the gradient, which is consistent with the predominance of light (small dense-core) vesicles in this species.
Gene_expression (present) of dopamine beta-hydroxylase in vesicles associated with dopamine and noradrenaline
2) Confidence 0.67 Published 1984 Journal Neuroscience Section Abstract Doc Link 6527783 Disease Relevance 0 Pain Relevance 0.37
The presence of vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine amide (PHI), neuropeptide tyrosine, dopamine-beta-hydroxylase (DBH), cholecystokinin/gastrin, glutamate and galanin was more scarce.
Gene_expression (presence) of DBH associated with glutamate, dopamine, neuropeptide and cholecystokinin
3) Confidence 0.64 Published 1997 Journal Arch. Oral Biol. Section Abstract Doc Link 9134126 Disease Relevance 0 Pain Relevance 0.55
The presence of vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine amide (PHI), neuropeptide tyrosine, dopamine-beta-hydroxylase (DBH), cholecystokinin/gastrin, glutamate and galanin was more scarce.
Gene_expression (presence) of dopamine-beta-hydroxylase associated with glutamate, dopamine, neuropeptide and cholecystokinin
4) Confidence 0.64 Published 1997 Journal Arch. Oral Biol. Section Abstract Doc Link 9134126 Disease Relevance 0 Pain Relevance 0.55
Substance P, VIP, CCK, and DBH processes were also present.
Gene_expression (present) of DBH associated with cholecystokinin and substance p
5) Confidence 0.64 Published 1984 Journal J. Comp. Neurol. Section Abstract Doc Link 6205027 Disease Relevance 0 Pain Relevance 1.38
To define further the developmental history of cholinergic sympathetic neurons, we have used immunocytochemical techniques to examine developing and mature sweat gland innervation for the presence of the catecholamine synthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and for two neuropeptides present in the mature cholinergic innervation, vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (CGRP).
Gene_expression (presence) of DBH in sweat gland associated with dopamine, catecholamine, neuropeptide and calcitonin gene-related peptide
6) Confidence 0.64 Published 1988 Journal Dev. Biol. Section Abstract Doc Link 2893756 Disease Relevance 0 Pain Relevance 0.33
To define further the developmental history of cholinergic sympathetic neurons, we have used immunocytochemical techniques to examine developing and mature sweat gland innervation for the presence of the catecholamine synthetic enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) and for two neuropeptides present in the mature cholinergic innervation, vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (CGRP).
Gene_expression (presence) of dopamine beta-hydroxylase in sweat gland associated with dopamine, catecholamine, neuropeptide and calcitonin gene-related peptide
7) Confidence 0.64 Published 1988 Journal Dev. Biol. Section Abstract Doc Link 2893756 Disease Relevance 0 Pain Relevance 0.33
In the present study we determined whether (i) growth-associated protein-43 and dopamine beta-hydroxylase or substance P were co-expressed in the same neurons prior to cord injury, and (ii) these patterns of expression changed after injury.
Gene_expression (co-expressed) of dopamine beta-hydroxylase in neurons associated with dopamine, injury and substance p
8) Confidence 0.63 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336136 Disease Relevance 1.13 Pain Relevance 0.65
Rat adrenal medulla: levels of chromogranins, enkephalins, dopamine beta-hydroxylase and of the amine transporter are changed by nervous activity and hypophysectomy.
Gene_expression (levels) of dopamine beta-hydroxylase in adrenal medulla associated with medulla, dopamine and enkephalin
9) Confidence 0.63 Published 1987 Journal Neuroscience Section Title Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.83
Insulin treatment induced increased levels of enkephalins, dopamine beta-hydroxylase, the amine carrier and of chromogranin B whereas catecholamines, cytochrome b-561 and chromagranin A remained slightly below control levels.
Gene_expression (levels) of dopamine beta-hydroxylase associated with dopamine, catecholamine and enkephalin
10) Confidence 0.63 Published 1987 Journal Neuroscience Section Abstract Doc Link 2819772 Disease Relevance 0 Pain Relevance 0.66
In contrast, enkephalinlike immunoreactivity (ELI), tyrosine hydroxylase, and dopamine-beta-hydroxylase were detected in processes and a few perikarya located outside the ventrolateral parabrachial region.
Gene_expression (detected) of dopamine-beta-hydroxylase associated with dopamine and parabrachial
11) Confidence 0.62 Published 1984 Journal J. Comp. Neurol. Section Abstract Doc Link 6205025 Disease Relevance 0 Pain Relevance 0.77
In contrast, TH and DBH mRNA levels in the SCG, but not in adrenal medulla, were elevated by ACTH administration, similar to the levels attained after immobilization.
Gene_expression (levels) of DBH mRNA in SCG associated with medulla
12) Confidence 0.60 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.57 Pain Relevance 0.30
The study implicates hormonal involvement in the stress-induced changes in TH, DBH, NPY, and proenkephalin gene expression in sympathetic ganglia.
Gene_expression (expression) of DBH in sympathetic associated with stress
13) Confidence 0.60 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.61 Pain Relevance 0.28
Like the catecholamine synthesizing enzymes TH and DBH, enkephalin-like immunoreactivity was localized to perikarya, proximal processes and varicose axon terminals within the area postrema and the adjacent mNTS.
Gene_expression (synthesizing) of DBH in proximal associated with catecholamine and enkephalin
14) Confidence 0.60 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0.10 Pain Relevance 0.64
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Gene_expression (synthesizing) of DBH in area postrema associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
15) Confidence 0.60 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.41
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Gene_expression (synthesizing) of dopamine-beta-hydroxylase in area postrema associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
16) Confidence 0.60 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.41
Norepinephrine (NE), a vital neurotransmitter in both the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) through the oxidation of dopamine (DA) to NE.
Gene_expression (synthesized) of DBH in peripheral nervous systems associated with dopamine and neurotransmitter
17) Confidence 0.59 Published 2002 Journal Clin. Auton. Res. Section Abstract Doc Link 12102462 Disease Relevance 0.52 Pain Relevance 0.23
The content of DA in blood and blood plasma, the characteristics of GABA and the opiate receptors of the brain, the activity of DBH, COMT, MAO, the content of cAMP and cGMP in brain tissue, as well as the expression of the gene c-fos were studied.
Gene_expression (expression) of DBH in brain associated with gaba and opiate
18) Confidence 0.58 Published 1994 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 7969881 Disease Relevance 0.25 Pain Relevance 0.19
In the upper dermis, the DBH-IR fibers were rarely located around blood vessels, but were often observed wrapping around calcitonin gene-related peptide (CGRP)-IR fibers (Figure 2C, arrows).
Gene_expression (wrapping) of DBH-IR in dermis associated with calcitonin gene-related peptide
19) Confidence 0.55 Published 2008 Journal Mol Pain Section Body Doc Link PMC2637239 Disease Relevance 0.36 Pain Relevance 0.26
The catecholamine synthesizing enzymes TH and DBH, found jointly only in noradrenergic and adrenergic neurons, were localized in cells having a similar morphology and topographical distribution.
Gene_expression (synthesizing) of DBH in adrenergic neurons associated with catecholamine
20) Confidence 0.52 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0.05 Pain Relevance 0.42

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