INT144366

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.43
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
nucleus accumbens 2
brain 2
blood 1
cerebrospinal fluid 1
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
bDMF 4 100.00 Very High Very High Very High
Nucleus accumbens 1 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
cytokine 6 99.52 Very High Very High Very High
chemokine 4 99.52 Very High Very High Very High
Pain 5 98.92 Very High Very High Very High
antagonist 9 97.68 Very High Very High Very High
Inflammation 3 96.04 Very High Very High Very High
addiction 6 91.44 High High
Disease Link Frequency Relevance Heat
Pain 5 98.92 Very High Very High Very High
Targeted Disruption 6 96.68 Very High Very High Very High
INFLAMMATION 4 96.04 Very High Very High Very High
Drug Dependence 6 85.48 High High
Necrosis 2 75.00 Quite High
Cancer 2 75.00 Quite High
Parkinsonian Disorders 7 45.52 Quite Low
Parkinson's Disease 41 44.64 Quite Low
Disease 15 34.72 Quite Low
Cognitive Disorder 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Leu-Ile inhibits METH- or MOR-induced place preference and sensitization by attenuating the METH- or MOR-induced increase in extracellular dopamine levels in the nucleus accumbens via the induction of GDNF and TNF-alpha expression.
Negative_regulation (attenuating) of Positive_regulation (induction) of GDNF in nucleus accumbens associated with nucleus accumbens, dopamine and morphine
1) Confidence 0.41 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17538232 Disease Relevance 0.72 Pain Relevance 1.00
The increase in striatal GDNF mRNA levels induced by a single injection of
                   LY379268 peaked after 3 h (Fig.
                       1D) and was prevented by the preferential mGlu2/3 receptor
                   antagonist, LY341495 (1 mg/kg, i.p.), which had no effect on its own (Fig. 1E). 
Negative_regulation (prevented) of Positive_regulation (increase) of GDNF associated with antagonist
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.11
NM_007540.3 Mus musculus brain derived neurotrophic factor (BDNF), mRNA
Negative_regulation (brain) of Positive_regulation (derived) of neurotrophic factor in brain associated with bdmf
3) Confidence 0.05 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0 Pain Relevance 0.20
Glial cell line-derived neurotrophic factor is increased in cerebrospinal fluid but decreased in blood during long-term pain.
Negative_regulation (decreased) of in blood Positive_regulation (increased) of neurotrophic factor in cerebrospinal fluid associated with chemokine and pain
4) Confidence 0.03 Published 2010 Journal J. Neuroimmunol. Section Title Doc Link 20129677 Disease Relevance 0.70 Pain Relevance 1.11

General Comments

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