INT144386

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.01
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP2D6) small molecule metabolic process (CYP2D6) oxidoreductase activity (CYP2D6)
endoplasmic reticulum (CYP2D6)
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 44 81.88 Quite High
headache 5 70.92 Quite High
Antihistamine 2 63.36 Quite High
Serotonin 9 59.76 Quite High
Dextromethorphan 30 59.44 Quite High
agonist 2 58.24 Quite High
Triptan 1 57.20 Quite High
Calcium channel 1 50.96 Quite High
fluoxetine 1 48.92 Quite Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 1 93.96 High High
Sprains And Strains 2 91.96 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 91.64 High High
Hypersensitivity 1 72.40 Quite High
Headache 5 70.92 Quite High
Vomiting 111 66.24 Quite High
Dizziness 2 62.28 Quite High
Constipation 3 61.52 Quite High
Reprotox - General 2 1 53.60 Quite High
Post-operative Nausea 59 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1.0 V) the electrochemical approach appeared to be unsuccessful in reducing the immobilized CYP2D6 completely, and failed to generate any reduced active enzyme at all.
Positive_regulation (unsuccessful) of Negative_regulation (reducing) of CYP2D6
1) Confidence 0.49 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0.03
Tipranavir is metabolized by cytochrome P450 (CYP) 3A and, when combined with ritonavir in vitro, causes inhibition of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A in addition to induction of glucuronidase and the drug transporter P-glycoprotein.
Positive_regulation (causes) of Negative_regulation (inhibition) of CYP2D6
2) Confidence 0.41 Published 2007 Journal Pharmacotherapy Section Abstract Doc Link 17542771 Disease Relevance 0.24 Pain Relevance 0.17
Palonosetron does not cause inhibition or induction of the main hepatic enzyme systems including CYP2D6, CYP1A2 and CYP3A4/5, so the risk of significant drug interactions is low.119 However an adverse reaction with apomorphine that presented as profound hypotension and altered consciousness has been reported, so concomitant use is contraindicated.128


Neg (not) Positive_regulation (cause) of Negative_regulation (inhibition) of CYP2D6 associated with pressure volume 2 under development
3) Confidence 0.28 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697527 Disease Relevance 0.77 Pain Relevance 0.20

General Comments

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