INT14439

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1987
Last Reported 2005
Negated 1
Speculated 4
Reported most in Abstract
Documents 12
Total Number 16
Disease Relevance 2.25
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GAL) Golgi apparatus (GAL) cellular_component (GAL)
response to stress (GAL) cytoplasm (GAL)
Anatomy Link Frequency
ileum 1
LES 1
jejunum 1
nerve 1
ganglion cells 1
GAL (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 4 100.00 Very High Very High Very High
substance P 10 99.96 Very High Very High Very High
tetrodotoxin 3 99.84 Very High Very High Very High
Neuropeptide 18 99.04 Very High Very High Very High
hyperexcitability 2 98.68 Very High Very High Very High
Calcitonin gene-related peptide 1 98.52 Very High Very High Very High
Central nervous system 2 98.08 Very High Very High Very High
Spinal cord 6 97.96 Very High Very High Very High
Enkephalin 5 96.12 Very High Very High Very High
Pain 6 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 98.84 Very High Very High Very High
Pain 6 95.68 Very High Very High Very High
Nociception 5 89.24 High High
Pancreatic Cancer 3 86.16 High High
Pancreatitis 1 82.72 Quite High
Depression 2 82.04 Quite High
Pancreatic Ductal Carcinoma 1 77.64 Quite High
Nervous System Injury 2 69.96 Quite High
Malignant Neoplastic Disease 1 69.88 Quite High
Skin Cancer 2 66.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).
Regulation (regulation) of GALN1R
1) Confidence 0.61 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9425310 Disease Relevance 0.16 Pain Relevance 0.12
Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).
Regulation (regulation) of galanin
2) Confidence 0.61 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9425310 Disease Relevance 0.16 Pain Relevance 0.12
Immunoreactivity for galanin, vasoactive intestinal polypeptide, calcitonin gene-related peptide, substance P, neuromedin U, enkephalin, somatostatin and neuropeptide Y was found in varicose and non-varicose nerve fibres of both submucosal ganglionic plexuses, albeit with a distinct distributional pattern.
Regulation (Immunoreactivity) of galanin in nerve associated with neuropeptide, somatostatin, enkephalin, substance p and calcitonin gene-related peptide
3) Confidence 0.44 Published 1990 Journal Cell Tissue Res. Section Abstract Doc Link 1694106 Disease Relevance 0 Pain Relevance 0.81
Competitive inhibition assays with various MoAbs and lectins indicated that the epitope recognized by LD-B1 antibody involves the carbohydrate sequence Gal beta 1----3Gal beta 1----3(or 4)GlcNAc beta 1----3Gal.
Regulation (involves) of Gal
4) Confidence 0.44 Published 1990 Journal Exp. Mol. Pathol. Section Abstract Doc Link 1702061 Disease Relevance 0.39 Pain Relevance 0.08
Furthermore, the contractile response of galanin on the LES was also not affected by tetrodotoxin.
Neg (not) Regulation (affected) of galanin in LES associated with tetrodotoxin
5) Confidence 0.44 Published 1987 Journal Life Sci. Section Abstract Doc Link 2447463 Disease Relevance 0 Pain Relevance 0.13
DT completely blunted the GH response to ARG, whereas it attenuated the GH response to GAL, but not at a statistically significant level.
Regulation (response) of GAL
6) Confidence 0.44 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8570858 Disease Relevance 0 Pain Relevance 0.21
The effects of intrathecal galanin message-associated peptide (GMAP) on the flexor reflex in rats.
Regulation (effects) of GMAP associated with intrathecal
7) Confidence 0.43 Published 1995 Journal Regul. Pept. Section Title Doc Link 8570856 Disease Relevance 0.23 Pain Relevance 0.42
The present study examined the effects of four fragments of GMAP-(1-60), GMAP-(1-12), GMAP-(10-24), GMAP-(25-44) and GMAP-(37-60), on the flexor reflex and compared them with the effects of the complete peptide sequence.
Spec (examined) Regulation (effects) of GMAP
8) Confidence 0.39 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016918 Disease Relevance 0.18 Pain Relevance 0.29
The present study examined the effects of four fragments of GMAP-(1-60), GMAP-(1-12), GMAP-(10-24), GMAP-(25-44) and GMAP-(37-60), on the flexor reflex and compared them with the effects of the complete peptide sequence.
Spec (examined) Regulation (effects) of GMAP
9) Confidence 0.39 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016918 Disease Relevance 0.18 Pain Relevance 0.28
So far information is limited, but it has been demonstrated that galanin is expressed in DRGs and possibly also regulated.
Spec (possibly) Regulation (regulated) of galanin
10) Confidence 0.35 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15893817 Disease Relevance 0.42 Pain Relevance 0.37
The present study demonstrates that tetrodotoxin-induced blockade of neuronal activity fully mimicked the effect of axotomy (transection of the septohippocampal fibers) in the neurons of the nucleus of the diagonal band, and caused a dramatic, although temporary, up-regulation of galanin immunoreactivity and galanin mRNA without significant alteration in choline acetyltransferase expression.
Regulation (immunoreactivity) of galanin in nucleus associated with tetrodotoxin
11) Confidence 0.26 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7523176 Disease Relevance 0 Pain Relevance 0.13
The effect of galanin, a 29 amino-acid peptide, on intestinal smooth muscles was studied in guinea-pig ileum.
Regulation (effect) of galanin in ileum
12) Confidence 0.26 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2473912 Disease Relevance 0 Pain Relevance 0
Galanin immunoreactivity after Sep Pak and immunoextraction correlated (r = 0.74, p < 0.001) the levels being higher after immunoextraction (p < 0.001).
Regulation (immunoreactivity) of Galanin
13) Confidence 0.22 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 15971152 Disease Relevance 0.07 Pain Relevance 0.10
The present study was designed to examine the effect of galanin, M15 and M35 on longitudinal jejunal smooth muscle strips isolated from humans and rats, and to localize galanin-immunoreactivity in human jejunum.
Spec (examine) Regulation (effect) of galanin in jejunum
14) Confidence 0.20 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595426 Disease Relevance 0 Pain Relevance 0.22
NPY, SP, Gal and TH immunoreactivities were present in almost all of the ganglion cells.
Regulation (immunoreactivities) of Gal in ganglion cells associated with ganglion cysts and substance p
15) Confidence 0.14 Published 2000 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 10916853 Disease Relevance 0.46 Pain Relevance 0.60
Increased levels of GMAP, VIP and nitric oxide synthase, and their mRNAs, in lumbar dorsal root ganglia of the rat following systemic resiniferatoxin treatment.
Regulation (levels) of GMAP in dorsal root ganglia
16) Confidence 0.05 Published 1995 Journal Neuroreport Section Title Doc Link 8595209 Disease Relevance 0 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox