INT144391

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 42
Total Number 46
Disease Relevance 40.48
Pain Relevance 10.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RETN) extracellular region (RETN) nucleus (RETN)
biological_process (RETN)
Anatomy Link Frequency
plasma 5
macrophages 4
blood 4
monocytes 3
adipocytes 3
RETN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1391 100.00 Very High Very High Very High
Inflammatory mediators 105 100.00 Very High Very High Very High
cytokine 840 99.96 Very High Very High Very High
chemokine 312 99.52 Very High Very High Very High
Chronic pancreatitis 9 99.28 Very High Very High Very High
Neurotransmitter 18 99.18 Very High Very High Very High
depression 24 98.20 Very High Very High Very High
Central nervous system 40 97.88 Very High Very High Very High
Inflammatory marker 27 97.68 Very High Very High Very High
fibrosis 21 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1640 100.00 Very High Very High Very High
Diabetes Mellitus 422 99.84 Very High Very High Very High
Infection 368 99.84 Very High Very High Very High
Obesity 355 99.84 Very High Very High Very High
Viral Meningitis 28 99.36 Very High Very High Very High
Pancreatitis 9 99.28 Very High Very High Very High
Nicotine Addiction 56 99.24 Very High Very High Very High
Drug Induced Neurotoxicity 8 99.00 Very High Very High Very High
Diabetic Foot Ulcer 150 98.92 Very High Very High Very High
Stable Angina Pectoris 1 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lowering levels of resistin, CRP and TNF?
Gene_expression (levels) of resistin
1) Confidence 0.75 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291335 Disease Relevance 0.94 Pain Relevance 0.08
Plasma concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, resistin, plasminogen activator inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) were measured.
Gene_expression (concentrations) of resistin in Plasma
2) Confidence 0.65 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2148106 Disease Relevance 1.14 Pain Relevance 0.24
The possibility that antioxidants might act on resistin expression and levels has been suggested by a few studies on animals: retinoic acid inhibits the expression of resistin in mice [24], and the antioxidant seleno-methionine, which increases the activity of glutathione peroxidase in endothelial cells, completely blocks vasomotor dysfunction induced by resistin in porcine arteries [35].
Gene_expression (expression) of resistin in endothelial cells
3) Confidence 0.65 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.72 Pain Relevance 0.24
This suggested a specific direct effect of antioxidant substances on resistin expression from monocytes/macrophages.
Gene_expression (expression) of resistin in macrophages
4) Confidence 0.57 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.71 Pain Relevance 0.17
Overall, levels of resistin in blood fell substantially over the course of the trial among the individuals in the vitamin C supplementation group, but not in the control arm of the trial, and this difference between groups was statistically significant.
Gene_expression (levels) of resistin in blood
5) Confidence 0.57 Published 2007 Journal PLoS Clinical Trials Section Abstract Doc Link PMC1865087 Disease Relevance 0.36 Pain Relevance 0.03
In June–July 2005, a total of 80 eligible participants were enrolled and submitted in the morning, at fasting, to measurements of weight, waist circumference, and blood pressure, and to determinations of serum glucose, total cholesterol, HDL cholesterol, triglyceride, insulin, high-sensitivity CRP (hs-CRP), vitamin A, vitamin C, vitamin E, oxidized and reduced glutathione, NT, and resistin levels.
Gene_expression (levels) of resistin in blood associated with disorder of lipid metabolism
6) Confidence 0.57 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.35 Pain Relevance 0.03
The possibility that antioxidants might act on resistin expression and levels has been suggested by a few studies on animals: retinoic acid inhibits the expression of resistin in mice [24], and the antioxidant seleno-methionine, which increases the activity of glutathione peroxidase in endothelial cells, completely blocks vasomotor dysfunction induced by resistin in porcine arteries [35].
Gene_expression (expression) of resistin in endothelial cells
7) Confidence 0.57 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.67 Pain Relevance 0.21
Editorial Commentary

Background: Resistin is a hormone that is produced by fat cells.

Gene_expression (produced) of Resistin in fat cells associated with obesity
8) Confidence 0.50 Published 2007 Journal PLoS Clinical Trials Section Abstract Doc Link PMC1865087 Disease Relevance 0.51 Pain Relevance 0.05
However, it is quite unlikely that this could represent a source of measurement bias, since all the end points (e.g., the relationship between vitamin C and resistin levels) were blood measurements, blindly assessed by the same laboratory.
Gene_expression (levels) of resistin in blood
9) Confidence 0.49 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.60 Pain Relevance 0.10
The primary outcome of the trial was the change in resistin levels in blood, and the researchers also looked at the levels of other biochemical variables in blood, such as fasting glucose, insulin, cholesterol, fatty acids, and nitrotyrosine.
Gene_expression (levels) of resistin in blood
10) Confidence 0.49 Published 2007 Journal PLoS Clinical Trials Section Abstract Doc Link PMC1865087 Disease Relevance 0.57 Pain Relevance 0
METHODS: Plasma resistin levels were determined by means of enzyme-linked immunosorbent assay (ELISA) in 46 patients with unstable angina (UAP), 37 with stable angina (SAP) and 31 control subjects.
Gene_expression (levels) of resistin in Plasma
11) Confidence 0.48 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17543176 Disease Relevance 0.10 Pain Relevance 0
Striking differences in the genomic organization and cellular source of resistin in rodents versus humans make the biological effects found in the mouse not readily transferable to humans [4–6].
Gene_expression (source) of resistin
12) Confidence 0.44 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.61 Pain Relevance 0.06
Participants were stratified according to age, sex, smoking habits, body mass index, and fasting levels of glucose, hs-CRP, vitamin C, and resistin.
Gene_expression (levels) of resistin in body associated with nicotine addiction and obesity
13) Confidence 0.44 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.48 Pain Relevance 0.14
However, in humans, resistin is expressed at very low concentrations in adipose cells [2], but at high levels in mononuclear leukocytes, macrophages, spleen cells, and bone marrow cells [3].
Gene_expression (expressed) of resistin in spleen
14) Confidence 0.44 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.48 Pain Relevance 0
Retinoic acid, the acid form of vitamin A, inhibited the expression of resistin in mice and reduced the higher resistin levels of ten men affected by psoriasis [24,25].
Gene_expression (expression) of resistin associated with psoriasis
15) Confidence 0.44 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.65 Pain Relevance 0.25
Resistin was originally found to be related to proteins induced during lung inflammation [14], and the likelihood that it may be involved in the inflammation process [4,12,15–22] is suggested by the high expression levels of resistin in leukocytes, the associations between this protein and inflammatory markers, and the resistin's ability to stimulate in vivo inflammatory cytokines.
Gene_expression (expression) of resistin in leukocytes associated with inflammation, inflammatory marker, pneumonia and cytokine
16) Confidence 0.44 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.94 Pain Relevance 0.27
This suggests a specific direct effect of antioxidant substances on resistin expression from monocytes/macrophages.


Gene_expression (expression) of resistin in macrophages
17) Confidence 0.44 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865087 Disease Relevance 0.36 Pain Relevance 0.09
On this basis the aim of our study was to evaluate plasma levels of adiponectin, resistin and IL-6 in subjects with diabetic foot in comparison with subjects without foot complications.


Gene_expression (levels) of resistin in plasma associated with diabetic foot ulcer
18) Confidence 0.43 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.99 Pain Relevance 0.35
Our findings concerning the higher plasma levels IL-6 plasma levels and resistin in diabetic subjects with foot ulceration in comparison with diabetics without foot complications may confirm this topics.
Gene_expression (levels) of resistin in foot associated with diabetes mellitus
19) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 1.59 Pain Relevance 0.26
Regarding to Adiponectin and Resistin determination, high sensitivity kits (Biovendor) were used; IL-6 was determined by the Diaclone ELISA kit.
Gene_expression (determination) of Resistin
20) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2946274 Disease Relevance 0.50 Pain Relevance 0.03

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