INT144393

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.96
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 2 95.88 Very High Very High Very High
Endogenous opioid 1 94.84 High High
hypoalgesia 1 93.68 High High
substance P 1 85.28 High High
Enkephalin 3 84.00 Quite High
Neuropeptide 1 83.04 Quite High
narcan 2 82.44 Quite High
antagonist 1 82.04 Quite High
opioid receptor 2 81.60 Quite High
Thermal hyperalgesia 4 74.92 Quite High
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 5 96.72 Very High Very High Very High
Hyperalgesia 6 95.88 Very High Very High Very High
Hypoalagesia 1 93.68 High High
Bone Cancer 1 75.00 Quite High
Inflammatory Pain 1 69.16 Quite High
Schizophrenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The selective inhibitor of eNOS L-NIO, but not the inhibitors of nNOS (N-omega-propyl-L-arginine) or iNOS (1400w), blocked the effect of loperamide on osteosarcoma-induced hyperalgesia and also the endogenous opioid peripheral hypoalgesia that appears during the initial stages of the development of this osteosarcoma.
Negative_regulation (inhibitor) of Negative_regulation (inhibitors) of nNOS associated with hyperalgesia, endogenous opioid, hypoalgesia and osteogenic sarcomas
1) Confidence 0.32 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17543351 Disease Relevance 0.96 Pain Relevance 0.99
Although inhibition of PDE10A causes accumulation of both cAMP and cGMP, the increase in striatal cfos expression appears to depend on changes in cAMP, since the increase is present in mice deficient in nNOS which fail to increase cGMP in response to PDE10A inhibition.
Negative_regulation (present) of Negative_regulation (deficient) of nNOS
2) Confidence 0.08 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 19765598 Disease Relevance 0 Pain Relevance 0.17

General Comments

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