INT144396

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.25
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
spinal 4
neurons 1
platelet 1
astrocytes 1
synapses 1
P2rx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 26 99.54 Very High Very High Very High
qutenza 16 99.32 Very High Very High Very High
adenocard 25 98.84 Very High Very High Very High
Glutamate receptor 3 98.04 Very High Very High Very High
Kinase C 75 97.96 Very High Very High Very High
allodynia 27 95.84 Very High Very High Very High
nMDA receptor 5 95.12 Very High Very High Very High
Nucleus accumbens 22 94.88 High High
Sciatic nerve 1 91.20 High High
agonist 64 85.36 High High
Disease Link Frequency Relevance Heat
Pain 15 99.54 Very High Very High Very High
Death 14 98.96 Very High Very High Very High
Injury 49 96.08 Very High Very High Very High
Neuropathic Pain 34 95.84 Very High Very High Very High
Liver Disease 1 92.00 High High
Cv Unclassified Under Development 11 78.16 Quite High
Stroke 95 69.96 Quite High
Cicatrix 1 69.76 Quite High
Cv General 4 Under Development 10 69.68 Quite High
INFLAMMATION 14 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that the activation of P2X-receptors, most likely spinal P2X2/3-receptors on capsaicin-insensitive primary afferent neurons, triggers the induction of long-lasting allodynia through NMDA receptors, and the induction and early maintenance phase, but not the late phase, is mediated through the functions of spinal glial cells.
Positive_regulation (activation) of P2X in spinal associated with allodynia, qutenza and nmda receptor
1) Confidence 0.49 Published 2007 Journal Neuroscience Section Abstract Doc Link 17543465 Disease Relevance 0.43 Pain Relevance 0.77
Several lines of evidence suggest that extracellular ATP plays a role in pain signaling through the activation of ionotropic P2X-receptors, especially homomeric P2X3- and heteromeric P2X2/3-receptors on capsaicin-sensitive and -insensitive primary afferent neurons, respectively, at peripheral and spinal sites.
Positive_regulation (activation) of P2X in spinal associated with pain and qutenza
2) Confidence 0.49 Published 2007 Journal Neuroscience Section Abstract Doc Link 17543465 Disease Relevance 0.37 Pain Relevance 0.63
Several lines of evidence suggest that extracellular ATP plays a role in pain signaling through the activation of ionotropic P2X-receptors, especially homomeric P2X3- and heteromeric P2X2/3-receptors on capsaicin-sensitive and -insensitive primary afferent neurons, respectively, at peripheral and spinal sites.
Positive_regulation (activation) of P2X in spinal associated with pain and qutenza
3) Confidence 0.49 Published 2007 Journal Neuroscience Section Abstract Doc Link 17543465 Disease Relevance 0.39 Pain Relevance 0.68
Taken together, these results suggest that the activation of P2X-receptors, most likely spinal P2X2/3-receptors on capsaicin-insensitive primary afferent neurons, triggers the induction of long-lasting allodynia through NMDA receptors, and the induction and early maintenance phase, but not the late phase, is mediated through the functions of spinal glial cells.
Positive_regulation (activation) of P2X in spinal associated with allodynia, qutenza and nmda receptor
4) Confidence 0.49 Published 2007 Journal Neuroscience Section Abstract Doc Link 17543465 Disease Relevance 0.43 Pain Relevance 0.76
However, this reduction results most likely from the time required for P2X1 receptors to recover from desensitisation as the peak amplitude responses recover after continual wash with extracellular solution.
Positive_regulation (required) of P2X
5) Confidence 0.49 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.03
Although there are few central synapses where fast neurotransmission is predominantly mediated via release of ATP and activation of postsynaptic P2X receptors (Edwards et al. 1992; Khakh & North, 2006; Burnstock, 2007), ATP can be released as a cotransmitter (Jo & Schlichter, 1999; see Pankratov et al. 2006 for review).
Positive_regulation (activation) of P2X in synapses
6) Confidence 0.45 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.20
with P2X1 receptors produced a 2.5-fold increase of the P2X1 receptor-mediated current that was blocked by the PKC inhibitor staurosporine and could be mimicked by PMA treatment of singly expressed P2X1 receptors.
Positive_regulation (increase) of P2X1 associated with kinase c
7) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.37
Upregulation of P2X1-IR at microglial cells, as found in this study, was described at activated astrocytes after stab-wound injury in the adult rat NAc [29].
Positive_regulation (Upregulation) of P2X1 in astrocytes associated with nucleus accumbens and injury
8) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.45 Pain Relevance 0.22
The ATP sensitivity and functional properties of P2X receptors vary widely; for example, P2X1 is activated by nanomolar concentrations of ATP, and desensitizes rapidly, whereas P2X7 requires high-micromolar concentrations of ATP, and does not appear to desensitize [16].
Positive_regulation (activated) of P2X1
9) Confidence 0.23 Published 2010 Journal Trends in Biochemical Sciences Section Body Doc Link PMC2824114 Disease Relevance 0.17 Pain Relevance 0.21
In addition, in this mixed model of differentiation and axotomy, the colocalization of ataxin-2 (ax-2, involved in resistance to degeneration phenomena, which may be lost after mutation)-immunopositive cells and P2X2 receptors was demonstrated in neurons, and post-lesional induction of P2X1 receptor and ax-2 immunoreactivity was reported as well [170].
Positive_regulation (induction) of P2X1 in neurons
10) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.40 Pain Relevance 0.14
Activation of the P2X1 and P2Y1 receptors leads to alteration in shape and initiates a weak and transient phase of platelet aggregation.
Positive_regulation (Activation) of P2X1 in platelet
11) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835559 Disease Relevance 0.61 Pain Relevance 0.20

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