INT144400

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 21.24
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cytosol (PTK2)
Anatomy Link Frequency
AsPC-1 20
colon 3
lymph node 2
platelet 2
liver 1
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 31 59.72 Quite High
endometriosis 2 50.00 Quite Low
Dismenorea 2 10.00 Low Low
metalloproteinase 28 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 731 99.92 Very High Very High Very High
Breast Cancer 75 99.46 Very High Very High Very High
Pancreatic Cancer 1502 99.44 Very High Very High Very High
Apoptosis 1189 99.36 Very High Very High Very High
Adhesions 295 98.52 Very High Very High Very High
Death 43 98.24 Very High Very High Very High
Malignant Neoplastic Disease 62 97.76 Very High Very High Very High
Metastasis 210 97.24 Very High Very High Very High
Reprotox - General 1 116 85.52 High High
Endometriosis (extended) 2 60.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION(S): The study showed a significant increase of FAK expression in the secretory endometrial tissues of women with endometriosis, a relationship between FAK expression and disease stage, pelvic pain, and serum steroid hormones.
Positive_regulation (increase) of Gene_expression (expression) of FAK
1) Confidence 0.70 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17543958 Disease Relevance 0.12 Pain Relevance 0
Moreover, inhibition of FAK phosphorylation by FRNK overexpression antagonized the effects of LN on survivin expression and Bad phosphorylation at Ser136 in AsPC-1 cells (Fig. 10D).
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK in AsPC-1
2) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.45 Pain Relevance 0
Similar results were obtained in Panc-1 cells stably transfected with the FAK RNAi2 plasmid (data not shown).
Positive_regulation (transfected) of Gene_expression (transfected) of FAK
3) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.50 Pain Relevance 0
The effect of LN on Akt activation was almost completely blocked by inhibition of FAK phosphorylation through either FAK RNAi or FRNK overexpression (Fig. 7A-B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK
4) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.16 Pain Relevance 0
Compared with control groups, pool cells overexpressing FRNK were more sensitive to Gem-induced apoptosis, which was demonstrated by an increased proportion of condensed nuclei, significantly higher of Annexin-V positivity (P < 0.05) and more cleaved caspase-3 protein expression.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of FRNK associated with apoptosis
5) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.73 Pain Relevance 0
Our studies found that LN induced FAK phosphorylation in a time-dependent manner in AsPC-1 cells, and FAK phosphorylation inhibition by either RNAi or FRNK overexpression antagonized the effect of LN on Gem chemoresistance.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK in AsPC-1
6) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.75 Pain Relevance 0
We further determined the effects of FRNK overexpression on Gem-induced apoptosis in Panc-1 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK associated with apoptosis
7) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.64 Pain Relevance 0
PF-228 is a more specific method to decrease FAK phosphorylation compared with FRNK overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK
8) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.40 Pain Relevance 0
In our study, FRNK overexpression enhanced Gem-induced cytotoxicity and apoptosis to a similar extent as FAK RNAi in Panc-1 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK associated with apoptosis
9) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.67 Pain Relevance 0
Thus, we investigated whether inhibition of FAK activity by FRNK overexpression might modulate these proteins and thereby regulate apoptosis in Panc-1 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK associated with apoptosis
10) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.71 Pain Relevance 0
Effects of FAK RNAi and FRNK overexpression on LN-mediated Gem chemoresistance in AsPC-1 cells
Positive_regulation (overexpression) of Gene_expression (overexpression) of FAK RNAi in AsPC-1
11) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.40 Pain Relevance 0
However, FRNK overexpression did not significantly affect the apoptosis of Panc-1 cells in the absence of Gem.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK associated with apoptosis
12) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.80 Pain Relevance 0
However, FRNK overexpression did not significantly affect Gem-induced apoptosis in AsPC-1 cells that had low level of pFAK (pY397).
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK in AsPC-1 associated with apoptosis
13) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.69 Pain Relevance 0
However, FRNK overexpression did not significantly affect Gem-induced apoptosis in AsPC-1 cells on plastic (Fig. 10B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK in AsPC-1 associated with apoptosis
14) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.50 Pain Relevance 0
Previous study in breast cancer cells has also found that FRNK overexpression inhibited the activation of FAK and PKB and thus enhanced chemotherapy-induced cell apoptosis [37].
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK associated with breast cancer and apoptosis
15) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.59 Pain Relevance 0
FAK expression and (or) phosphorylation was elevated in a variety of cancers and frequently correlated with malignant or metastatic disease and poor patient prognosis [12,13].
Positive_regulation (elevated) of Gene_expression (expression) of FAK associated with malignant neoplastic disease, cancer and metastasis
16) Confidence 0.66 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 1.52 Pain Relevance 0.06
Consistent with the results of FAK phosphorylation inhibition by FAK RNAi and FRNK overexpression, specific inhibition of FAK phosphorylation by PF-228 led to the corresponding inhibition of AKT but not ERK phosphorylation in Panc-1 cells and Aspc-1 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FAK RNAi
17) Confidence 0.48 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.49 Pain Relevance 0
Consistent with the results of FAK RNAi and FRNK overexpression, PF-228 rendered Panc-1 cells more sensitive to Gem-induced apoptosis (Fig. 12A-C), while in AsPC-1 cells PF-228 treatment antagonized LN-mediated Gem chemoresistance (Fig. 13A-C), which was demonstrated by an increased proportion of condensed nuclei, significantly higher of Annexin-V positivity (P < 0.05) and more cleaved caspase-3 protein expression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FRNK in AsPC-1 associated with apoptosis
18) Confidence 0.48 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.51 Pain Relevance 0
The effect of LN on Akt activation was almost completely blocked by inhibition of FAK phosphorylation through either FAK RNAi or FRNK overexpression (Fig. 7A-B).
Positive_regulation (overexpression) of Gene_expression (overexpression) of FAK RNAi
19) Confidence 0.48 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.21 Pain Relevance 0
Consistent with the results of FAK RNAi and FRNK overexpression, PF-228 rendered Panc-1 cells more sensitive to Gem-induced apoptosis (Fig. 12A-C), while in AsPC-1 cells PF-228 treatment antagonized LN-mediated Gem chemoresistance (Fig. 13A-C), which was demonstrated by an increased proportion of condensed nuclei, significantly higher of Annexin-V positivity (P < 0.05) and more cleaved caspase-3 protein expression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FAK RNAi in AsPC-1 associated with apoptosis
20) Confidence 0.48 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.51 Pain Relevance 0

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